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ProteomicsPTPN23-dependent ESCRT machinery functions as a cell death checkpoint in restraining multiple cell death pathways
In our study, a CRISPR screen of acute myeloid leukemia cells identifies protein tyrosine phosphatase non-receptor type 23 (PTPN23) as essential for survival. Loss of PTPN23 activates nuclear factor-kappa B, apoptotic, necroptotic, and pyroptotic pathways by causing the accumulation of death recepto...
ORGANISM(S): Homo Sapiens 
PXD056836 |
ProteomicsIdentification of ESCRT-related subunits in Trypanosoma brucei
Using cryomilling and proteomics approaches we expand the understanding of ESCRT-I complex in Trypanosoma brucei. We found two novel subunits of the trypanosoma complex using TbVPS23 as bait.
ORGANISM(S): Trypanosoma brucei 
2026-08-24 | PXD058826 | Pride
Trypanosoma Co-immunoprecipitation Vps23 Cryomilling Escrt-i (endosomal sorting complex required for transport-i) 
ProteomicsLEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation
Quantitative crosslinking analysis to probe in vitro conformational dynamics governing ESCRT-mediated nuclear envelope formation. CHMP7 was crosslinked with D12-BS3 while CHMP7 in the presence of LEM2 winged helix domain was crosslinked with H12-BS3. Samples were mixed after crosslinking and analy...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-01-24 | MSV000084837 | MassIVE
ProteomicsADAPT identifies an ESCRT complex composition that discriminates VCaP from LNCaP prostate cancer cell exosomes
Libraries of single-stranded oligodeoxynucleotides (ssODNs) can be enriched for sequences that specifically bind molecules on naïve complex biological samples like cells or tissues. Depending on the enrichment strategy, the ssODNs can identify molecules specifically associated with a defined biologi...
ORGANISM(S): Homo sapiens (Human) 
2020-01-13 | PXD011496 | Pride
Prostate cancer cells Escrt complex Aptamers Adapt Exosomes 
ProteomicsSelective microautophagy of proteasomes is initiated by ESCRT-0 and is promoted by proteasome ubiquitylation
The proteasome is central to proteolysis by the ubiquitin-proteasome system under normal growth conditions but is itself degraded through macroautophagy under nutrient stress. A recently described AMPactivated protein kinase (AMPK)-regulated endosomal sorting complex required for transport (ESCRT)-d...
ORGANISM(S): Saccharomyces Cerevisiae 
2022-02-06 | PXD031469 |
ProteomicsESCRT complexes in Giardia intestinalis (VPS36A)
To assess ESCRT subunit presence, distribution and main interactors, we performed iterative co-immunoprecipitation on recombinant Giardia subunits.
ORGANISM(S): Giardia lamblia ATCC 50803 
2021-04-10 | PXD016446 | Pride
Giardia Coip Escrt 
ProteomicsESCRT complexes in Giardia intestinalis (VPS25)
To assess ESCRT subunit presence, distribution and main interactors, we performed iterative co-immunoprecipitation on recombinant Giardia subunits.
ORGANISM(S): Giardia lamblia ATCC 50803 
2021-04-10 | PXD016448 | Pride
Giardia Coip Escrt 
ProteomicsESCRT complexes in Giardia intestinalis (VPS20L)
To access ESCRT subunit presence, distribution and main interactors, we performed iterative co-immunoprecipitation on recombinant Giardia subunits.
ORGANISM(S): Giardia lamblia ATCC 50803 
2021-04-10 | PXD016442 | Pride
Giardia Coip Escrt 
ProteomicsESCRT complexes in Giardia intestinalis (CHMP7)
To access ESCRT subunit presence, distribution and main interactors, we performed iterative co-immunoprecipitation on recombinant Giardia subunits.
ORGANISM(S): Giardia lamblia ATCC 50803 
2021-04-10 | PXD016487 | Pride
Giardia Coip Escrt 
GenomicsLASER couples damage sensing to ESCRT assembly for lysosome repair
LASER couples damage sensing to ESCRT assembly for lysosome repair
PRJNA1455520 | ENA
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