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MetabolomicsMetabolite of esculetin plays an important role in cytotoxic effects induced by chloroquine on porcine immature Sertoli cells

Chloroquine (CQ) is widely used in the therapy against malarial, tumor and recently the COVID-19 pandemic, as a lysosomotropic agent to inhibit the endolysosomal trafficking in the autophagy pathway. We previously reported that CQ (20 µM, 36 h) could reprogram transcriptome and impair multiple si...

2024-07-08 | MTBLS9273 | MetaboLights
ProteomicsEsculetin inhibits cancer cell glycolysis by binding tumor PGK2, GPD2, and GPI
Glycolysis can improve the tolerance of tissue cells to hypoxia, and its intermediates provide raw materials for the synthesis and metabolism of the tumor cells. If it can inhibit the activity of glycolysis-related enzymes and control the energy metabolism of tumor, it can be targeted for the treatm...
ORGANISM(S): Homo sapiens (Human) 
2020-03-03 | PXD017819 | Pride
Transcriptome Proteomics Microscale thermophoresis Esculetin Protein inhibitor Keywords: glycolysis Gpd2/gpi. 
ProteomicsThe target proteins phosphoglycerate kinase 2 (PGK2), glycerol-3-phosphate dehydrogenase (GPD2)GPD2 and glucose-6-phosphate isomerase (GPI) were screened by combining transcriptome, proteomics and reverse docking, then, we. We detected the binding constant of the active compound using microscale thermophoresis (MST). It was found that esculetin bound well with three potential target proteins.
The results of this study demonstrated that esculetin can affect the glucose metabolism by binding to glycolytic proteins, thus playing an anti-tumor role, and the pathway comprising these proteins which have direct interactions are a potential novel targets for tumor treatment by esculetin.
ORGANISM(S): Homo sapiens (Human) 
2020-01-20 | PXD017062 | Pride
Lc-msms Hepg2 
GenomicsEsculetin modulates postprandial cholesterol metabolism involved in phagocytosis of adipose tissue macrophages
Esculetin modulates postprandial cholesterol metabolism involved in phagocytosis of adipose tissue macrophages
PRJNA1045041 | ENA
GenomicsEsculetin inhibits cancer cell glycolysis by binding tumor PGK2, GPD2, and GPI
Esculetin inhibits cancer cell glycolysis by binding tumor PGK2, GPD2, and GPI
PRJNA599568 | ENA
GenomicsEsculetin modulates postprandial cholesterol metabolism involved in phagocytosis of adipose tissue macrophages
Postprandial dyslipidemia is a recognized risk factor for atherosclerosis. High-density lipoprotein (HDL)-mediated reverse cholesterol transport plays a crucial role in mitigating this risk by clearing postprandial lipids. This study aimed to investigate the impact of esculetin, a 4-Hydroxycoumarin,...
ORGANISM(S): Mus musculus 
2025-04-21 | GSE248616 | GEO
GenomicsEsculetin modulates postprandial cholesterol metabolism involved in phagocytosis of adipose tissue macrophages (RNA-Seq)
Esculetin modulates postprandial cholesterol metabolism involved in phagocytosis of adipose tissue macrophages (RNA-Seq)
PRJNA1157854 | ENA
TranscriptomicsEsculetin modulates postprandial cholesterol metabolism involved in phagocytosis of adipose tissue macrophages (RNA-Seq)
Postprandial dyslipidemia is a significant risk factor for atherosclerotic cardiovascular diseases. High-density lipoprotein (HDL)-driven reverse cholesterol transport (RCT) plays a crucial role in clearing postprandial lipids. In this study, we aimed to investigate the role of esculetin, a hypolipi...
ORGANISM(S): Mus musculus 
2025-04-21 | GSE276565 | GEO
GenomicsEsculetin promotes HDL-driven cholesterol excretion involved in CD36-mediated phagocytosis of adipose tissue macrophages and CEBPbeta
Esculetin promotes HDL-driven cholesterol excretion involved in CD36-mediated phagocytosis of adipose tissue macrophages and CEBPbeta
PRJNA982877 | ENA
TranscriptomicsEsculetin promotes HDL-driven cholesterol excretion involved in CD36-mediated phagocytosis of adipose tissue macrophages and CEBPbeta
Postprandial dyslipidemia is a recognized risk factor for atherosclerosis. High-density lipoprotein (HDL)-mediated reverse cholesterol transport plays a crucial role in mitigating this risk by clearing postprandial lipids. This study aimed to investigate the impact of esculetin, a 4-Hydroxycoumarin,...
ORGANISM(S): Mus musculus 
2024-06-12 | GSE234771 | GEO
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