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GenomicsA New Murine Esophageal Organoid Culture Method and Organoid-Driven Model of Esophageal Squamous Cell Neoplasia
A New Murine Esophageal Organoid Culture Method and Organoid-Driven Model of Esophageal Squamous Cell Neoplasia
PRJNA730569 | ENA
ProteomicsMsh2 depletion impairs cell differentiation, proliferation and metabolism in esophageal organoids
Due to rapid cell turnover, the esophageal stratified squamous epithelium must maintain homeostasis. This process is insured by a long-lived subpopulation of basal stem cells that express Keratin 15 (Krt15). However, the mechanisms that specifically control their characteristics, i.e. self-renewal, ...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-21 | PXD040810 | Pride
Esophageal organoid Msh2 Differentiation Homeostasis Clonogenicity 
UnknownA new murine esophageal organoid culture method and organoid-based model of esophageal squamous cell neoplasia.
Not available
S-EPMC8633967 | biostudies-literature
GenomicsEsophageal Adenocarcinoma Organoid Genomics
Single cell RNA-seq (scRNA-seq) of esophageal adenocarcinoma organoids to benchmark variant calling from 10X Genomics scRNA-seq data. Five EAC organoids were subjected to scRNA-seq and two included matched exome data.
EGAS00001005224 | EGA
TranscriptomicsA New Murine Esophageal Organoid Culture Method and Organoid-Driven Model of Esophageal Squamous Cell Neoplasia
We sought to develop esophageal minimum essential organoid culture medium (E-MEOM) for culturing murine esophageal organoids (EOs) and establishing an early ESCC model. We formulated E-MEOM that is sufficient to grow EOs from a single cell with clonal expansion, maintenance, and passage. From the IH...
ORGANISM(S): Mus musculus 
2021-11-17 | GSE174577 | GEO
TranscriptomicsNOTCH3 knockdown in non-transformed human esophageal cells
To determine the role of NOTCH3 in human esophageal epitheila homeostasis/squamous cell differentiation Zinc finger E-box binding (ZEB) proteins ZEB1 and ZEB2 are transcription factors essential in transforming growth factor (TGF)-β-mediated epithelial to mesenchymal transition (EMT), senescence an...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-27424 | biostudies-arrayexpress
GenomicsGene expression analysis of organoid model of human esophageal squamous cell carcinomas (ESCCs)
Gene expression analysis of organoid model of human esophageal squamous cell carcinomas (ESCCs)
PRJNA1121932 | ENA
UnknownEsophageal Organoids from Human Pluripotent Stem Cells Delineate Sox2 Functions during Esophageal Specification.
Not available
S-EPMC6225525 | biostudies-literature
UnknownOrganoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics.
Not available
S-EPMC6065407 | biostudies-literature
GenomicsPatient-Derived Tumor Organoid and Fibroblast Assembloid Models for interrogation of the tumor microenvironment in Esophageal Adenocarcinoma
Patient-Derived Tumor Organoid and Fibroblast Assembloid Models for interrogation of the tumor microenvironment in Esophageal Adenocarcinoma
PRJNA1160870 | ENA
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