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GenomicsBurkholderia sp. MSh2
Burkholderia sp. MSh2 Genome sequencing and assembly
PRJNA251789 | ENA
GenomicsMsh2-Lynch
Msh2-Lynch
PRJEB45308 | ENA
ProteomicsMsh2 depletion impairs cell differentiation, proliferation and metabolism in esophageal organoids
Due to rapid cell turnover, the esophageal stratified squamous epithelium must maintain homeostasis. This process is insured by a long-lived subpopulation of basal stem cells that express Keratin 15 (Krt15). However, the mechanisms that specifically control their characteristics, i.e. self-renewal, ...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-21 | PXD040810 | Pride
Esophageal organoid Msh2 Differentiation Homeostasis Clonogenicity 
ProteomicsDNA2 and MSH2 activities collectively mediate environmental chemical compound stabilized G4 for efficient telomere replication
G-quadruplexes (G4s) are widely existing stable DNA secondary structures in mammalian cells. A long-standing hypothesis is that timely resolution of G4s is needed for efficient and faithful DNA replication. In vitro, G4s may be unwound by helicases or alternatively resolved via DNA2 nuclease-mediate...
ORGANISM(S): Homo sapiens (Human) 
2025-08-07 | PXD059843 | Pride
G-quadruplex Msh2 Dna2 Telomere 
TranscriptomicsGene expression analysis of B cell lymphomas from representative IµHABcl6, IµHABcl6 Ung-/- Msh2-/-, and IµHABcl6 Msh2-/- mouse models.
Somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin (Ig) genes are genomic modification events that occur in germinal center (GC) B cells and are initiated through deamination of cytidine to uracil by activation induced cytidine deaminase (AID). Resulting uracil-guani...
ORGANISM(S): Mus musculus 
2015-12-08 | E-GEOD-48304 | biostudies-arrayexpress
TranscriptomicsIdentifying crossover locations in Arabidopsis thaliana wild type Col x CLC, msh2 Col x CLC and msh2 Col x Ler F2 populations using genotyping by sequencing.
Genomic DNA from 189 wild type Col x CLC, 191 msh2 Col x CLC or 187 msh2 Col x Ler F2 individuals was extracted using CTAB and used to generate sequencing libraries as described (Serra et al 2018 PNAS). Sequencing data was analysed to identify crossovers as previously reported, using the TIGER pipel...
ORGANISM(S): Arabidopsis thaliana 
2020-09-02 | E-MTAB-8252 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of leukemia-initiating cells of compound URE-/+::Msh2-/- mice
Expression profiling of FACS purified Lin-cKit+ cells from compound URE-/+::Msh2-/- mice with AML and control animals Analysis of gene expression in Lin-cKit+ cells from three URE-/+::Msh2-/- mice and four wild type controls
ORGANISM(S): Mus musculus 
2015-09-07 | E-GEOD-65668 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of leukemia-initiating cells of preleukemic compound URE-/+::Msh2-/- mice
Expression profiling of FACS purified Lin-cKit+ cells from preleukemic compound URE-/+::Msh2-/- mice and control animals (two separate pools of 3 mice each) Analysis of gene expression in Lin-cKit+ cells from two URE-/+::Msh2-/- mice and wild type control animals (two pools of three animals each)
ORGANISM(S): Mus musculus 
2015-09-07 | E-GEOD-65669 | biostudies-arrayexpress
TranscriptomicsIdentifying crossover locations in Arabidopsis thaliana msh2 Col-0 x Ct-1 F2 populations using genotyping-by-sequencing
Genomic DNA from 320 msh2 Col x Ct F2 individuals was extracted by CTAB and used to generate sequencing libraries as previously described (Hennig et al, 2018 G3). Sequencing data was analysed to identify crossovers using the TIGER pipeline as previously described (Rowan et al, 2015 G3; Yelina et al,...
ORGANISM(S): Arabidopsis thaliana 
2020-09-02 | E-MTAB-9370 | biostudies-arrayexpress
ClinicalMethotrexate in Metastatic Colorectal Cancer With MSH2 Deficiency
To assess the efficacy of methotrexate in a genetically selected population of patients with advanced colorectal cancer, who have loss of a particular gene, MSH2. The efficacy of methotrexate will be evaluated by the proportion of cases that have a significant response to treatment (objective respon...
2076124 | ecrin-mdr-crc
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