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ProteomicsRPA promotes processive ssDNA digestion by Dna2 via their bimodal interaction in Saccharomyces cerevisiae
Single-stranded DNA (ssDNA) widely exists as intermediates in DNA metabolic pathways. The ssDNA binding protein, RPA, not only protects the integrity of ssDNA, but also directs the downstream factor that signals or repairs the ssDNA intermediate. However, it remains unclear how these enzymes/factors...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-02-22 | PXD028637 | Pride
Ssdna Saccharomyces cerevisiae Dna2 Rpa 
ProteomicsDNA2 and MSH2 activities collectively mediate environmental chemical compound stabilized G4 for efficient telomere replication
G-quadruplexes (G4s) are widely existing stable DNA secondary structures in mammalian cells. A long-standing hypothesis is that timely resolution of G4s is needed for efficient and faithful DNA replication. In vitro, G4s may be unwound by helicases or alternatively resolved via DNA2 nuclease-mediate...
ORGANISM(S): Homo sapiens (Human) 
2025-08-07 | PXD059843 | Pride
G-quadruplex Msh2 Dna2 Telomere 
GenomicsA whole genome-screening strategy to identify DNA2 binding sites and genomic regions that require DNA2 for replication
A whole genome-screening strategy to identify DNA2 binding sites and genomic regions that require DNA2 for replication
PRJNA427827 | ENA
GenomicsTargeting DNA2 Overcomes Metabolic Reprogramming in Multiple Myeloma
Targeting DNA2 Overcomes Metabolic Reprogramming in Multiple Myeloma
PRJNA807285 | ENA
GenomicsA whole genome-screening strategy to identify DNA2 binding sites and genomic regions that require DNA2 for replication
We report that DNA2 predominantly bound to the centromeric α-satellite regions. The centromeric regions contained 58% of the DNA2-associated DNA, representing a 33.5-fold enrichment over genomic input. To define the under-replicated DNA regions in DNA2-null cells, we conducted whole-genome DNA seque...
ORGANISM(S): Homo sapiens 
2018-04-10 | GSE108619 | GEO
GenomicsDna2 removes toxic RPA-ssDNA flaps generated from meiotic recombination-associated DNA synthesis
Dna2 removes toxic RPA-ssDNA flaps generated from meiotic recombination-associated DNA synthesis
PRJNA899853 | ENA
UnknownThe iron-sulphur cluster in human DNA2 is required for all biochemical activities of DNA2.
Not available
S-EPMC7311471 | biostudies-literature
GenomicsDna2 removes toxic RPA-ssDNA flaps generated from meiotic recombination-associated DNA synthesis
During the repair of DNA double-strand breaks (DSBs), de novo synthesized DNA strand can displace the parental strand to generate single-strand DNA (ssDNA) flaps. Many programmed DSBs and thus many ssDNA flaps occur during meiosis. However, how these flaps are removed remains enigmatic. Here, we sho...
ORGANISM(S): Saccharomyces cerevisiae SK1 
2023-08-30 | GSE217628 | GEO
UnknownEnzymatic properties of the Caenorhabditis elegans Dna2 endonuclease/helicase and a species-specific interaction between RPA and Dna2.
Not available
S-EPMC552954 | biostudies-literature
TranscriptomicsTargeting DNA2 Overcomes Metabolic Reprogramming in Multiple Myeloma
Targeting DNA2 is synthetically lethal in myeloma cells that undergo metabolic adaptation and rely on oxidative phosphorylation to maintain survival after DNA damage activation.
ORGANISM(S): Homo sapiens 
2023-11-27 | GSE196766 | GEO
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