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ProteomicsEstrogen receptor beta isoforms interplay integrates nuclear and extra-nuclear signaling to modulate human granulosa cell growth
Estradiol (E2) is a central regulator of ovarian follicle development and granulosa cells (GCs) function, acting predominantly through estrogen receptor β (ERβ) in GCs. Human GCs co-express multiple ERβ isoforms (ERβ1, ERβ2, ERβ4 and ERβ5), yet how their relative abundance and crosstalk determine es...
ORGANISM(S): Homo sapiens (Human) 
2026-10-19 | PXD073667 | Pride
Signaling crosstalk Nuclear signaling Extra-nuclear signaling Estrogen receptor beta isoforms Cell growth Protein interactions Human granulosa cells Estradiol 
no omics definedTranscription profiling of breast cancer cells with TET-OFF regulated ERb expression treated with estradiol or ICI, an estrogen receptor antagonist
Assess the full impact of estrogen receptor beta on transcription by a full transcriptome analysis of ERa and ERb-mediated gene regulation in T47D breast cancer cell line with TET-OFF regulated ERb expression.
ORGANISM(S): Homo sapiens 
2007-12-17 | E-MEXP-969 | biostudies-arrayexpress
GenomicsDifferential effects of estrogen receptor beta isoforms on glioblastoma progression
Differential effects of estrogen receptor beta isoforms on glioblastoma progression
PRJNA412261 | ENA
TranscriptomicsTranscription profiling of human U2OS cells expressing estrogen receptor alpha and beta heterodimers and treated with 17beta-estradiol or 4OH-tamoxifen
U2OS-ERa, U2OS-ERb, and U2OS-ERab cells treated with 4HT or E2
ORGANISM(S): Homo sapiens 
2007-08-25 | E-GEOD-2292 | biostudies-arrayexpress
UnknownEstrogen receptor (ER)-beta isoforms: a key to understanding ER-beta signaling.
Not available
S-EPMC1552044 | biostudies-literature
UnknownThe Isoforms of Estrogen Receptor Alpha and Beta in Thyroid Cancer.
Not available
S-EPMC9263191 | biostudies-literature
UnknownDifferential Effects of Estrogen Receptor β Isoforms on Glioblastoma Progression.
Not available
S-EPMC6004261 | biostudies-literature
UnknownEstradiol Regulates mRNA Levels of Estrogen Receptor Beta 4 and Beta 5 Isoforms and Modulates Human Granulosa Cell Apoptosis.
Not available
S-EPMC8126246 | biostudies-literature
UnknownContrasting activities of estrogen receptor beta isoforms in triple negative breast cancer.
Not available
S-EPMC7867590 | biostudies-literature
TranscriptomicsEstrogen Receptor Beta Impacts Hormone-Induced Alternative mRNA Splicing in Breast Cancer Cells
Estrogens play an important role in breast cancer (BC) development and progression, where the two isoforms of the estrogen receptor (ER? and ER?) are generally co-expressed and mediate the effects of these hormones in cancer cells. ER? has been suggested to exert an antagonist role toward the oncoge...
ORGANISM(S): Homo sapiens 
2015-09-01 | E-GEOD-64590 | biostudies-arrayexpress
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