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MetabolomicsB cell expression of the enzyme PexRAP, an intermediary in ether lipid biosynthesis, promotes antibody responses and germinal center size.

The qualities of antibody (Ab) responses provided by B lymphocytes and their plasma cell (PC) descendants are crucial facets of responses to vaccines and microbes. Metabolic processes and products regulate aspects of B cell proliferation and differentiation into germinal center (GC) and PC states...

2026-04-13 | MTBLS13880 | MetaboLights
GenomicsEther lipid remodeling during neuronal differentiation prevents ferroptosis
Ether lipid remodeling during neuronal differentiation prevents ferroptosis
PRJNA1460824 | ENA
MetabolomicsThe lipid-metabolism enzyme ECI2 reduces neutrophil extracellular traps formation for colorectal cancer suppression
Abnormalities in ether lipid metabolism as well as the formation of neutrophil extracellular traps have recently been recognized as detrimental factors affecting tumorigenesis and progression. However, the role of abnormal ether lipid metabolism in colorectal cancer (CRC) evolution has not been repo...
2024-10-01 | MTBLS10323 | MetaboLights
TranscriptomicsEther lipid remodeling during neuronal differentiation prevents ferroptosis
Ferroptosis is a form of cell death driven by iron-dependent lipid peroxidation, with specific lipid species playing key roles in modulating susceptibility. Among these, ether lipids have shown conflicting effects, being linked to both protection and sensitization. Here, we dissect the relationship ...
ORGANISM(S): Homo sapiens 
2026-05-06 | GSE329743 | GEO
UnknownEther lipid deficiency disrupts lipid homeostasis leading to ferroptosis sensitivity.
Not available
S-EPMC9555615 | biostudies-literature
UnknownBifunctional Probes Reveal the Rules of Intracellular Ether Lipid Transport.
Not available
S-EPMC12603971 | biostudies-literature
UnknownDisturbed neurotransmitter homeostasis in ether lipid deficiency.
Not available
S-EPMC6548223 | biostudies-literature
UnknownA Caenorhabditis elegans model for ether lipid biosynthesis and function.
Not available
S-EPMC4727422 | biostudies-literature
UnknownOrphan enzymes in ether lipid metabolism.
Not available
S-EPMC3520006 | biostudies-literature
ProteomicsPeroxisome-derived ether lipids regulate lysosomal homeostasis through exocytosis control
Lysosomes and peroxisomes are essential for cellular homeostasis, yet how their activities are coordinated remains poorly understood. Here, we identify peroxisome-derived ether lipids as key regulators of lysosomal function. A genome-wide CRISPR/Cas9 screen in Mucolipidosis V (LYSET-deficient) cells...
ORGANISM(S): Homo sapiens (Human) 
2026-05-03 | PXD074652 | Pride
Human Lysosome Lyset Silac Ether-lipid Far1 
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