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TranscriptomicsTmem88a Mediates GATA-dependent Specification of Cardiomyocyte Progenitors by Restricting Canonical WNT Signaling
We sequenced mRNA from zebrafish wild-type embryos, gata5 morphants, gata6 morphants, and gata5/6 morphants at bud and 6-somite developmental stages to identify genes co-operatively regulated by gata5 and gata6 during cardiomyocyte progenitor specification. Samples were collected in duplicate, with ...
ORGANISM(S): Danio rerio 
2013-10-21 | E-GEOD-44026 | biostudies-arrayexpress
TranscriptomicsThe Translation Initiation Factor eIF3h Targets Specific Transcripts to Polysomes during Embryogenesis
We have sequenced the polysome-associated translating mRNAs from stage-matched wild-type and eif3ha morphant embryos at ~24 hpf stage to identify transcripts translationally regulated by eIF3ha. As a control, we have also sequenced total mRNAs from the stage-matched wild-type and eif3ha morphants as...
ORGANISM(S): Danio rerio 
2013-06-05 | E-GEOD-44584 | biostudies-arrayexpress
TranscriptomicsComparsion of Smad1 and Smad5 Dependent Transcript Profiles in Zebrafish
The BMP signaling pathway regulates multiple steps of hematopoiesis, mediated through receptor-regulated Smads, including Smad1 and Smad5. Here we use loss-of-function approaches in zebrafish to compare the roles of Smad1 and Smad5 during embryonic hematopoiesis. Microarray experiments revealed that...
ORGANISM(S): Danio rerio 
2010-06-25 | E-GEOD-8903 | biostudies-arrayexpress
UnknownLow-dose IL-2 reduces IL-21+ T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes.
Not available
S-EPMC9705541 | biostudies-literature
TranscriptomicsGATA factors efficiently direct cardiac fate from ESCs
Gata5 efficiently promotes cardiomyocyte fate from murine ESCs.By removing serum from the culture conditions, GATA4 and GATA6 are each also able to efficiently promote cardiogenesis in ESC derivatives, with some distinctions. Thus, GATA factors can function in ESC derivatives upstream of other car...
ORGANISM(S): Mus musculus 
2013-02-02 | E-GEOD-43831 | biostudies-arrayexpress
UnknownRegulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial.
Not available
S-EPMC5058548 | biostudies-literature
UnknownThe impact of viral mutations on recognition by SARS-CoV-2 specific T cells.
Not available
S-EPMC8552693 | biostudies-literature
TranscriptomicsEarly passage mouse induced pluripotent stem (iPS) cells derivated from various somatic cell origins
Induced pluripotent stem (iPS) cells have been derived from various somatic cell populations through ectopic expression of defined factors. It remains unclear whether iPS cells generated from different cell types are molecularly and functionally similar. Here, we show that iPS cells obtained from fi...
ORGANISM(S): Mus musculus 
2010-07-19 | E-GEOD-22908 | biostudies-arrayexpress
UnknownPatient-specific genomics and cross-species functional analysis implicate LRP2 in hypoplastic left heart syndrome.
Not available
S-EPMC7581429 | biostudies-literature
UnknownIncreases in arm volume predict lymphoedema and quality of life deficits after axillary surgery: a prospective cohort study.
Not available
S-EPMC7341763 | biostudies-literature
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