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TranscriptomicsRNA-Seq of tissue and plasma extracellular vesicles of breast cancer patients at the time of diagnosis and after the breast surgery
In the current study, we performed deep sequencing analysis of the RNA cargo of plasma EVs collected at the time of diagnosis, during and after the NAC and up to 18 months after the surgery and matched tumor and normal tissues from 35 patients with locally advanced BC, and 30 cancer-free females.
ORGANISM(S): Homo sapiens 
2022-10-24 | E-MTAB-12014 | biostudies-arrayexpress
ProteomicsMGAT3 and MGAT5 overexpression alters the protein cargo of extracellular vesicles released by metastatic melanoma cells
Extracellular vesicles (EVs) are potential non-invasive diagnostic, prognostic, and therapeutic tools. Additionally, they are important contributors to tumorigenesis. Glycosylation has been found to modulate the composition of the EV proteome, and increased amounts of beta 1,6-branched N-glycans, sy...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-11-08 | MSV000096340 | MassIVE
TranscriptomicsBAG6KO impacts extracellular vesicle mRNA cargo
The mRNA cargo of B-16V and B-16V-delta-BAG6 cells was sequenced with RNA seq.
ORGANISM(S): Mus musculus 
2019-11-29 | E-MTAB-7123 | biostudies-arrayexpress
TranscriptomicsOsteoblasts secrete miRNA-containing extracellular vesicles that enhance expansion of human umbilical cord blood cells
Osteolineage cells represent one of the critical bone marrow niche components that support maintenance of hematopoietic stem and progenitor cells (HSPCs). Recent studies demonstrate that extracellular vesicles (EVs) regulate stem cell development via horizontal transfer of bioactive cargo, including...
ORGANISM(S): Homo sapiens 
2016-10-05 | E-MTAB-4560 | biostudies-arrayexpress
TranscriptomicsCharacterization of tumor extracellular vesicle RNA cargo
Comparative RNA profiling between tumor cells and their secreted extracellular vesicles. Results revealed enrichment in genes involved in cellular migration and metastasis in extracellular vesicles, in agreement with their role as mediators of tumor progression. Mice were orthotoplically transplante...
ORGANISM(S): Homo sapiens 
2015-03-05 | E-GEOD-66488 | biostudies-arrayexpress
TranscriptomicsTesticular germ cell tumour cells release microRNA containing extracellular vesicles that induce phenotypic and genotypic changes in cells of the tumour microenvironment
Malignant germ-cell-tumours (GCTs) are characterised by microRNA (miRNA/miR-) dysregulation, with universal over-expression of miR-371~373 and miR-302/367 clusters regardless of patient age, tumour site, or subtype (seminoma/yolk-sac-tumour/embryonal carcinoma). These miRNAs are released into the bl...
ORGANISM(S): Homo sapiens 
2023-09-30 | E-MTAB-13322 | biostudies-arrayexpress
ProteomicsTemporal changes in the protein cargo of extracellular vesicles and resultant immune reprogramming after severe burn injury in humans and mice.
Introduction Severe injury, including burn trauma, leads to profound immune dysfunction, yet the mechanisms driving these changes remain incompletely defined. This lack of understanding has hindered efforts to modulate the immune response effectively. Additionally, a clear biomarker profile to guide...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-05-21 | PXD062615 | Pride
Protein cargo Extracellular vesicles Macrophages Burn injury Thermal injury Burn injury 
GenomicsRNA-Protein Cargo Delineates Distinct Subpopulations of Cancer-Derived Extracellular Vesicles
RNA-Protein Cargo Delineates Distinct Subpopulations of Cancer-Derived Extracellular Vesicles
PRJNA968017 | ENA
GenomicsPostprandial transfer of colostral extracellular vesicles and their protein and miRNA cargo in neonatal calves
Postprandial transfer of colostral extracellular vesicles and their protein and miRNA cargo in neonatal calves
PRJEB28002 | ENA
ProteomicsHuman T-cells EVs LC-MSMS - Extracellular Vesicle Subtypes Released From Activated or Apoptotic T-Lymphocytes Carry a Specific and Stimulus-Dependent Protein Cargo
As it is likely that different stimuli promote the release of distinct EV populations, we analyzed EVs from human lymphocytes considering the respective release stimuli (activation vs. apoptosis induction). Morphology and size were analyzed by electron microscopy and nanoparticle tracking analysis. ...
ORGANISM(S): Homo sapiens (Human) 
2018-03-15 | PXD009074 | Pride
Lc-msms Exosomes Microvesicles Evs Apoptosis 
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