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ProteomicsSulfisoxazole inhibits exosome secretion for potential breast cancer treatment
Inhibitors of the secretion of cancer exosomes, which promote cancer progression and metastasis, can not only accelerate exosome biology research but also offer therapeutic benefits for cancer patients. We identified sulfisoxazole (SFX) which inhibits exosome secretion from breast cancer cells. SFX,...
ORGANISM(S): Homo sapiens (Human) 
2019-11-13 | PXD012689 | Pride
Breast cancer Sulfisoxazole Exosome Lc-ms/ms 
TranscriptomicsTumor exosome integrins determine organotropic metastasis
Stephen Paget first proposed, in 1889, that organ distribution of metastases is a non-random event, yet metastatic organotropism remains one of the greatest mysteries in cancer biology. Here, we demonstrate that exosomes released by lung-, liver- and brain-tropic tumor cells fuse preferentially with...
ORGANISM(S): Homo sapiens 
2015-06-17 | E-GEOD-68919 | biostudies-arrayexpress
ProteomicsHuh-7 exosomes and HBV
Hepatitis B virus (HBV) infection could cause hepatitis, liver cirrhosis and hepatocellular carcinoma. HBV-mediated pathogenesis is only partially understood, but X protein (HBx) reportedly possesses oncogenic potential. Exosomes are small membrane vesicles with diverse functions released by various...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080794 | MassIVE
TranscriptomicsExosome-mediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA)
Background: Docosahexaenoic acid (DHA) is a natural compound with anticancer and anti-angiogenesis activity that is currently under investigation as both a preventative agent and an adjuvant to breast cancer therapy. However, the precise mechanisms of DHA’s anticancer activities are unclear. It is u...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-70432 | biostudies-arrayexpress
TranscriptomicsProfile the RNA composition of cell-free saliva and salivary exosomes
We compared the transcriptomic content of salivary exosomes vs. whole saliva via microarray (Affymetrix HU133 plus 2.0). Unstimulated saliva samples and derived exosome-like microvesicles were obtained from 3 healthy volunteers and processed for RNA isolation and microarray analysis.
ORGANISM(S): Homo sapiens 
2014-09-10 | E-GEOD-50700 | biostudies-arrayexpress
ProteomicsPTPN23 downregulation by WDR4 Determines the Exosome Secretion Fate of MVB to Promote Cancer Metastasis and Immune Evasion
Exosomes play pleiotropic tumor-promoting functions and are originated from a diversion of endocytic pathway. In late endocytic trafficking, multivesicular bodies (MVBs) are directed to lysosomes for degradation or secreted as exosomes. However, the mechanism controlling different fates of MVBs rema...
ORGANISM(S): Homo sapiens (Human) 
2025-01-24 | PXD050029 | Pride
Ubiquitination Endocytic trafficking Actin remodeling Nsclc Extracellular vesicles Immune checkpoint Immune evasion Exosome secretion Exosome Cancer metastasis Evs Lysosomal degradation 
GenomicsUltrasound-Amplified Exosome Secretion and Antibody-Free SERS Profiling for APOE Genotype-Dependent Signatures
Ultrasound-Amplified Exosome Secretion and Antibody-Free SERS Profiling for APOE Genotype-Dependent Signatures
PRJNA1333919 | ENA
UnknownCRABP1-complexes in exosome secretion.
Not available
S-EPMC11285139 | biostudies-literature
TranscriptomicsDynamics of intercellular and extracellular (exosomal) miRNAs in hypoxic RPMI8226 cells
Recently, the existence of extracellular miRNAs enclosed in exosomes has raised the possibility that they play an important role in cell-cell communication. To gain more insight into cell-cell communication via exosomal miRNAs, we investigated whether or not tumor cells exposed to hypoxia secrete ex...
ORGANISM(S): Homo sapiens 
2013-12-03 | E-GEOD-45388 | biostudies-arrayexpress
TranscriptomicsDynamics of intercellular and extracellular (exosomal) miRNAs in hypoxic K562 cells
Recently, the existence of extracellular miRNAs enclosed in exosomes has raised the possibility that they play an important role in cell-cell communication. To gain more insight into cell-cell communication via exosomal miRNAs, we investigated whether or not tumor cells exposed to hypoxia secrete ex...
ORGANISM(S): Homo sapiens 
2013-12-03 | E-GEOD-45289 | biostudies-arrayexpress
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