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ProteomicsNon-canonical EphA2 signaling is a driver of tumor-endothelial cell interactions and metastatic dissemination in BRAF inhibitor resistant melanoma: Expression Proteomics
Acquired BRAF/MEK inhibitor resistance in melanoma results in a new transcriptional state associated with increased risk of metastasis. Here, we identified non-canonical EphA2 signaling as a driver of the resistance-associated metastatic state. We used mass spectrometry-based proteomic and phenotypi...
ORGANISM(S): Homo sapiens (Human) 
2020-11-18 | PXD020242 | Pride
Melanoma Braf inhibitor Expression proteomics. ephrin a2 Drug resistance 
ProteomicsNon-canonical EphA2 signaling is a driver of tumor-endothelial cell interactions and metastatic dissemination in BRAF inhibitor resistant melanoma
Acquired BRAF/MEK inhibitor resistance in melanoma results in a new transcriptional state associated with increased risk of metastasis. Here, we identified non-canonical EphA2 signaling as a driver of the resistance-associated metastatic state. We used mass spectrometry-based proteomic and phenotypi...
ORGANISM(S): Homo sapiens (Human) 
2020-11-18 | PXD020250 | Pride
Phosphotyrosine. ephrin a2 Melanoma Braf inhibitor Drug resistance 
ProteomicsNon-canonical EphA2 signaling is a driver of tumor-endothelial cell interactions and metastatic dissemination in BRAF inhibitor resistant melanoma: Phosphoproteomics
Acquired BRAF/MEK inhibitor resistance in melanoma results in a new transcriptional state associated with increased risk of metastasis. Here, we identified non-canonical EphA2 signaling as a driver of the resistance-associated metastatic state. We used mass spectrometry-based proteomic and phenotypi...
ORGANISM(S): Homo sapiens (Human) 
2020-11-18 | PXD020241 | Pride
Melanoma Phosphoproteomics. ephrin a2 Braf inhibitor Drug resistance 
ProteomicsHypothalamic Proteomics analysis of lipopolysaccharide (LPS)-induced depressed mice
Hypothalamic dysfunction is a key pathological factor in inflammation-associated depression. In the present study, isobaric tags for relative-absolute quantitation (iTRAQ) combined with mass spectrometry were employed to detect the proteomes in the hypothalamus of the lipopolysaccharide (LPS)-induce...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-09 | PXD016040 | Pride
Depression Hypothalamus Lipopolysaccharide Itraq lc-ms/ms Brain tissue 
ProteomicsDetermining kinome changes in response to Cytomegalovirus US28 expression and identifying US28 interacting proteins
Cytomegalovirus (CMV) reactivation of latent infection following immune dysregulation remains a serious risk for patients, often causing significant morbidity and mortality. Herein, we demonstrate the CMV-encoded GPCR, US28, in coordination with cellular Ephrin receptor A2 (EphA2), attenuates MAPK s...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD033391 | Pride
Viral infection Affinity purification-mass spectrometry Kinome 
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