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Cohesin supercoils DNA during loop extrusion
Members of the apicomplexans are defined by apical cytoskeletal structures and secretory or-ganelles, tailored for motility and invasion. Gliding is powered by the actomyosin-dependent rearward translocation of apically secreted transmembrane adhesins. In Toxoplasma gondii, the conoid, composed of a...
ORGANISM(S): Toxoplasma gondii GT1 
2023-08-31 | PXD031816 | Pride
Pancreatic cancer is one of the most deadly cancers with a 5 year survival rate of about 5%. Therapeutic options are limited, especially for patients that present with late state disease and metastasis. Although the metastatic burden of pancreatic cancer is usually high, little is known about the ...
ORGANISM(S): Mus musculus 
Dynamic genome folding plays a crucial role in cellular functions, including V(D)J recombination at the immunoglobulin kappa (Igκ) locus for antibody generation. This process involves frequent recombination between Jκ and Vκ gene segments over a 3.2 Mb region in both deletional and inversional orien...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-20 | PXD058006 | Pride
The energetics and physiological impact of cohesin extrusion
RNA polymerases as moving barriers to condensin loop extrusion
Basal cell extrusion primes pluripotent cells for differentiation
Heterochromatin diversity modulates genome compartmentalization and loop extrusion barriers [HiC]
Characterization of induced cohesin loop extrusion trajectories in living cells [Hi-C]
Characterization of induced cohesin loop extrusion trajectories in living cells [ATAC-seq]
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