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MetabolomicsF-actin dynamics couples sphingolipid metabolism to epithelial barrier integrity in chronic colitis
Intestinal barrier dysfunction is a hallmark of gastrointestinal disorders, including inflammatory bowel diseases (IBD). In IBD, the disruption of the gut barrier causes liquid loss and persistent immune response. Understanding the cellular events underlying epithelial barrier disruption during chro...
2026-04-01 | MTBLS14166 | MetaboLights
ProteomicsMolecular basis of F-actin regulation and sarcomere assembly via myotilin
Sarcomeres, the basic contractile units of striated muscle cells, contain arrays of thin (actin) and thick (myosin) filaments that slide past each other during contraction. The Ig-like domain containing protein myotilin provides structural integrity to Z-discs—the boundaries between adjacent sarcome...
ORGANISM(S): Homo sapiens (Human) 
2021-02-22 | PXD024301 | Pride
Sarcomeric z-disc  f-actin binding  myotilin  α-actinin-2  integrative structural model of f-actin:myotilin  competitive tropomyosin binding  z-disc-assembly regulation Cross-linking mass spectrometry Lc-ms/ms 
ProteomicsPlasma membrane deformation by one-dimensional wetting triggers the formation of a branched F-actin network in endothelial cells
Membrane deformation by one-dimensional (1D) wetting, a physical process driven by the interaction of the plasma membrane with adhesive nanofibers, triggers the formation of filopodium-like plasma membrane protrusions. In these protrusions, F-actin reorganization occurs after membrane deformation. H...
ORGANISM(S): Neisseria meningitidis serogroup C (strain 8013) Homo sapiens (Human) 
2026-05-13 | PXD045648 | Pride
Plasma membrane deformation Branched f-actin network 
GenomicsTranscriptome analysis after disruption of nuclear F-actin in mouse embryos
Transcriptome analysis after disruption of nuclear F-actin in mouse embryos
PRJNA521538 | ENA
Proteomicsstudy of actin interactome in Alzheimers disease mouse model
Filamentous actin (F-actin) is one of the major cytoskeleton proteins present in dendritic spines and it is an essential component for defining dendritic spine morphology. We have shown that synaptosomal F-actin levels were significantly decreased in APP/PS1 mice as early as one month of age. The mo...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD050802 | Pride
F-actin loss Alzheimers disease Synapse 
GenomicsF-actin dynamics couples sphingolipid metabolism to epithelial barrier integrity in chronic colitis
F-actin dynamics couples sphingolipid metabolism to epithelial barrier integrity in chronic colitis
PRJNA1481546 | ENA
TranscriptomicsTranscriptome analysis after disruption of nuclear F-actin in mouse embryos
We find that filamentous actin (F-actin) is formed in pronuclei of mouse zygotes, disruption of which resulted in abnormal development of mouse embryos. To further explain the molecular mechanism, transcriptome analysis was performed following the artificial disruption of nuclear F-actin by overexpr...
ORGANISM(S): Mus musculus 
2020-06-30 | GSE126317 | GEO
GenomicsThe regulatory effect and mechanism of F-actin gene on the response of cadmium toxicity in farmland Pardosa pseudoannulata
The regulatory effect and mechanism of F-actin gene on the response of cadmium toxicity in farmland Pardosa pseudoannulata
PRJNA1199481 | ENA
GenomicsF-actin dynamics regulates mammalian organ growth and cell fate maintenance
F-actin dynamics regulates mammalian organ growth and cell fate maintenance
PRJNA480812 | ENA
TranscriptomicsThe regulatory effect and mechanism of F-actin gene on the response of cadmium toxicity in farmland Pardosa pseudoannulata
Reveal the sequence characteristics of key genes of F-actin; RNAi technology was used to investigate the regulatory effect of F-actin gene on cadmium contamination of Pardosa pseudoannulata, and to elucidate the response mechanism of F-actin in regulating spiders to cadmium pollution.
ORGANISM(S): Pardosa pseudoannulata 
2025-06-30 | GSE284523 | GEO
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