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Amyloidosis is a disorder characterized by the formation of extracellular amyloid deposits. Immunoglobulin light-chain amyloidosis the most common form of amyloidosis can appear as a local disorder presented with mild symptoms or as a life threatening systemic disease. Identification of the protein...
ORGANISM(S): Homo sapiens (Human) 
2014-05-29 | PXD000743 | Pride
Spatial transcriptomics of murine eyelid
Identification of genes involved in sebaceous gland carcinoma of the eyelid
Embryonic eyelid closure is a critical step of mammalian ocular surface development involving the forward movement and ultimate fusion of the upper and lower eyelids. Although its underlying mechanism of action is not fully understood, a functional mitogen-activated protein kinase kinase kinase 1 (M...
ORGANISM(S): Mus musculus 
Embryonic eyelid closure is a critical step of mammalian ocular surface development involving the forward movement and ultimate fusion of the upper and lower eyelids. Although its underlying mechanism of action is not fully understood, a functional mitogen-activated protein kinase kinase kinase 1 (M...
ORGANISM(S): Mus musculus 
2012-09-01 | GSE39240 | GEO
Sebaceous gland carcinoma is the frequent malignant tumor of the eyelid. However, there is limited understanding of how altered gene expression of sebaceous gland carcinoma of the eyelid related to the pathogenesis. In this study, to identify genes involved in sebaceous gland carcinoma of the eyelid...
ORGANISM(S): Homo sapiens 
2019-01-25 | GSE125582 | GEO
Basal cell carcinoma (BCC) is the most frequent malignant tumor of the eyelid. However, there is limited understanding of how altered gene expression of BCC of the eyelid related to the pathogenesis. In this study, to identify genes involved in basal cell carcinoma of the eyelid, global-scale gene e...
ORGANISM(S): Homo sapiens 
2017-09-05 | GSE103439 | GEO
EGR1 is an early growth response zinc finger transcription factor with broad actions, including in differentiation, mitogenesis, tumor suppression, and neuronal plasticity. Here we demonstrate that Egr1-/- C57BL/6-background mice have normal eyelid development, but back-crossing to BALB/c background...
ORGANISM(S): Mus musculus 
2017-07-30 | GSE100690 | GEO
Differentially expressed miRNAs for sebaceous gland carcinoma of the eyelid and TP53 mutation
Meibomian glands (MGs) are specialized holocrine sebaceous glands embedded in the tarsal plate of the eyelids. The cell heterogeneity of MGs is not well characterized. In this study, we performed a spatial transcriptomic analysis of murine eyelid using the 10X Visium platform.
ORGANISM(S): Mus musculus 
2025-01-21 | GSE274497 | GEO
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