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TranscriptomicsChange in gene expression in Chlamydomonas reinhardtii upon heat shock and feeding with hemin and Mg-protoporphyrin
This SuperSeries is composed of the following subset Series: GSE20859: Change in gene expression in Chlamydomonas reinhardtii upon heat shock GSE20860: Change in gene expression in Chlamydomonas reinhardtii upon feeding with hemin and Mg-protoporphyrin Refer to individual Series
ORGANISM(S): Chlamydomonas reinhardtii 
2011-03-11 | E-GEOD-20861 | biostudies-arrayexpress
ProteomicsAnalysis of coagulation factor IX in bioreactor cell culture media predicts yield and quality of purified product
Coagulation factor IX (FIX) is a highly complex post-translationally modified human serum glycoprotein and a high-value biopharmaceutical. The quality of recombinant FIX (rFIX), especially complete -carboxylation, is critical for rFIX clinical efficacy. Changes in bioreactor operating conditions dur...
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2021-03-29 | PXD018229 | Pride
Gamma-carboxylation Mass spectrometry Glycoproteomics Cho Host cell proteins Coagulation factor 
ProteomicsSpecialized shuttle proteins recognize and target type IX secretion effectors
Members of the phylum Bacteroidota utilize the type IX secretion system (T9SS) to transport diverse substrates into the environment or onto their surface. T9SS substrates feature a Sec-dependent signal peptide for export to the periplasm and a conserved C-terminal domain (CTD), recognized by the T9S...
ORGANISM(S): Flavobacterium johnsoniae 
2025-09-03 | PXD065655 | Pride
Type ix secretion Lc-msms Secretion signal Bacteroidota Flavobacterium 
TranscriptomicsCharacterization of protoporphytin IX effects on X-ray irradiation in Hela cells in vitro
Hela cells were used to evaluate the protoporphytin IX (PpIX) effects on X-ray irradiation. Treatment conditions were (1) control group (untreated cells); (2) cells treated with 1 μg /ml PpIX for 6 hours; (3) cells irradiated with 3Gy X-rays; (4) cells treated with 1 μg /ml PpIX for 6 hours prior ...
ORGANISM(S): Homo sapiens 
2015-01-21 | E-GEOD-61805 | biostudies-arrayexpress
TranscriptomicsRecombinant and plasma-derived Factor VIII products induce distinct splenic cytokine microenvironments in hemophilia A
To investigate the gene expression in dendritic cells after treating hemiphilic mice with HBSS, plasma derived or recombinant factor VIII Gene expression in dendritic cells were measured 24 hours post treatment Hemophilic mice with treated with either (HBSS, rFVIII or pdFVIII) 24 hours post treatmen...
ORGANISM(S): Mus musculus 
2010-05-19 | E-GEOD-15809 | biostudies-arrayexpress
GenomicsA CpG mutational hotspot in a ONECUT (HNF6) binding site accounts for the prevalent variant of Hemophilia B Leyden
Hemophilia B, or the 'Royal Disease', arises from mutations in the Coagulation Factor IX (F9) gene. Mutations within the F9 promoter are associated with a remarkable form of the disease, termed Hemophilia B Leyden, in which symptoms ameliorate after puberty. Mutations at the -5/-6 site account for t...
ORGANISM(S): Mus musculus 
2013-03-06 | E-MTAB-890 | biostudies-arrayexpress
UnknownIntraarticular factor IX protein or gene replacement protects against development of hemophilic synovitis in the absence of circulating factor IX.
Not available
S-EPMC2954682 | biostudies-literature
UnknownA Highly Productive CHO Cell Line Secreting Human Blood Clotting Factor IX.
Not available
S-EPMC5916734 | biostudies-literature
UnknownHemophilia B Gene Therapy with a High-Specific-Activity Factor IX Variant.
Not available
S-EPMC6029626 | biostudies-literature
GenomicsGenome wide CRISPR/Cas9 screen identifies the coagulation factor IX (F9) as a regulator of senescence
Genome wide CRISPR/Cas9 screen identifies the coagulation factor IX (F9) as a regulator of senescence
PRJNA791842 | ENA
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