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TranscriptomicsSingle-cell RNA sequencing of germ-free zebrafish embryos
The present study was conducted in the frame of the EU-funded Graphene Flagship project. We previously evaluated the impact of graphene oxide (GO) on the gut microbiome in adult zebrafish by performing 16S rRNA gene sequencing in wild-type versus AhR-deficient zebrafish. Here, we performed single-c...
ORGANISM(S): Danio rerio 
2022-07-22 | E-MTAB-11984 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA sequencing of lck-GFP transgenic zebrafish
The present study was conducted in the frame of the EU-funded Graphene Flagship project. The aim is to evaluate the impact of graphene oxide (GO) on the (innate) immune system using zebrafish as a model. We previously performed single-cell RNA-sequencing of germ-free zebrafish embryos exposed to GO ...
ORGANISM(S): Danio rerio 
2022-07-23 | E-MTAB-11991 | biostudies-arrayexpress
TranscriptomicsSystems biology approaches reveal low-dose effects of nanoparticles
Here, we show that systems biology approaches can uncover mechanisms underlying cellular responses to nanomaterials. Using RNA Seq, we found that cationic nanoparticles are capable of triggering down-regulation of cell cycle-related genes in primary human bronchial epithelial cells at doses that do ...
ORGANISM(S): Homo sapiens 
2015-01-17 | E-MTAB-2397 | biostudies-arrayexpress
TranscriptomicsOvercoming chemoresistance in B lymphoma cells: elucidating the role of NF-kB in caspase-independent apoptosis by transcriptomic assessment.
Although therapy responsiveness to therapy in Burkitt lymphoma (BL) is high, relapsed disease and and chemoresistance remain a clinical challenge, and complete mechanisms underlying BL chemoresistance and how it can be circumvented is yet to be fully elucidated. In this study we present data showing...
ORGANISM(S): Homo sapiens 
2014-01-19 | E-GEOD-31258 | biostudies-arrayexpress
TranscriptomicsCo-targeting of the PI3K pathway improves the response of BRCA1 deficient breast cancer cells to PARP1 inhibition
Although pre-clinical and clinical studies on PARP1 inhibitors, alone and in combination with DNA-damaging agents, show promising results, further ways to improve and broaden the scope of application of this therapeutic approach are warranted. To this end, we have investigated the possibility of imp...
ORGANISM(S): Homo sapiens 
2012-01-19 | E-GEOD-34817 | biostudies-arrayexpress
TranscriptomicsNanotoxicogenomic study of ZnO and TiO2 responses (Affymetrix)
A comprehensive in vitro assessment of two commercial metal oxide nanoparticles, TiO2 and ZnO, was performed using human monocyte-derived macrophages (HMDM), monocyte-derived dendritic cells (MDDC), and T cell leukemia-derived cell line (Jurkat). TiO2 nanoparticles were found to be non-toxic whereas...
ORGANISM(S): Homo sapiens 
2013-07-25 | E-GEOD-39330 | biostudies-arrayexpress
TranscriptomicsNanotoxicogenomic study of ZnO and TiO2 responses (Illumina)
A comprehensive in vitro assessment of two commercial metal oxide nanoparticles, TiO2 and ZnO, was performed using human monocyte-derived macrophages (HMDM), monocyte-derived dendritic cells (MDDC), and T cell leukemia-derived cell line (Jurkat). TiO2 nanoparticles were found to be non-toxic whereas...
ORGANISM(S): Homo sapiens 
2013-07-25 | E-GEOD-39316 | biostudies-arrayexpress
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