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MetabolomicsRP-based analysis of human faecal samples using the ZenoTOF 7600

This study contains replicated measurements of a reference human fecal sample from BioIVT. It serves as test and training data for metabolite annotation.

2025-08-07 | MTBLS8356 | MetaboLights
ProteomicsFaecal Proteases and Immune Signatures Drive Subtype-Specific Enteric Neuronal Activation in IBS
Background: Luminal proteases have been implicated in epithelial barrier dysfunction and visceral hypersensitivity in irritable bowel syndrome (IBS), yet their impact on the enteric nervous system (ENS), the principal regulator of gastrointestinal function, remains unknown. We investigated whether ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-10 | PXD071836 | Pride
Protease-activated receptors (pars) Irritable bowel syndrome Serine and cysteine protease activity Faecal supernatant proteomics Luminal–neuronal signalling axis 
ProteomicsQuantitative label-based canine faecal proteomics
In small animals, diarrhoea is a regular presentation, the aetiology of which can be varied, from an isolated self-limiting event to more serious episodes requiring symptomatic and supportive treatment. Chronic diarrhoea, defined as diarrhoea lasting longer than 3 weeks, is a relatively common probl...
ORGANISM(S): Canis lupus 
2022-08-29 | PXD017454 | Pride
Faecal proteomics Dog Chronic diarrhoea Tandem mass tags 
ProteomicsGut microbial functional maturation and succession during early life
The evolutional trajectory of gut microbial colonization from birth has been shown to prime for health later in life. Here, we combined cultivation-independent 16S rRNA gene sequencing and metaproteomics to investigate the functional maturation of gut microbiota in faecal samples from full-term heal...
ORGANISM(S): Homo sapiens (Human) 
2018-07-16 | PXD009056 | Pride
Gut microbiome  infants  metaproteomics  early life 
ProteomicsDifferences in the self proteome of human feaces with different dietary protein.
19 men were split into two groups. 10 were provided with a diet of twice the recommended daily intake of protein and 9 were provided meals with the recommended dietary intake of protein. Faecal samples were collected after 10 weeks on the diet. This project looked at determining any qualitative diff...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD021424 | Pride
Proteins Feaces Protein diet 
ProteomicsStool metaproteomics of children with islet autoimmunity
The gastrointestinal ecosystem is a highly complex environment with a profound influence on human health. Inflammation in the gut, linked to an altered gut microbiome has been associated with the development of multiple human conditions including type 1 diabetes (T1D). Viruses infecting the gastroin...
ORGANISM(S): Homo sapiens (Human) 
2022-08-22 | PXD032997 | Pride
T1d metaproteome 
ProteomicsProteome and peptidome analyses of mouse caecal contents and Paraprevotella clara culture supernatants
Caecal contents from three specific pathogen-free (SPF) mice, and three germ-free (GF) mice were analyzed by DIA-MS (SWATH-MS) using TripleTOF 5600+ (SCIEX). Paraprevotella clara (P. clara) culture supernatants nontreated and treated tunicamycin or 2-fluro-L-fucose (2F-Fuc) were analyzed by DIA-MS u...
ORGANISM(S): Paraprevotella Clara Mus Musculus (mouse) 
2022-06-29 | PXD027678 | JPOST Repository
ProteomicsA Metaproteomic Workflow for Sample Preparation and Data Analysis Applied to Mouse Faeces: 1
Many diseases have been associated with gut microbiome abnormalities. The root cause of such diseases is not only due to bacterial dysbiosis, but also to change in bacterial functions, which are best studied by proteomic approaches. Although bacterial proteomics is well established, metaproteomics i...
ORGANISM(S): mouse gut metagenome 
2022-02-15 | PXD020695 | Pride
Mus musculus Taxonomy Metaproteomics Metagenome 
ProteomicsA Metaproteomic Workflow for Sample Preparation and Data Analysis Applied to Mouse Faeces: 4
A Metaproteomic Workflow for Sample Preparation and Data Analysis Applied to Mouse Faeces: 1 MTD project_description Many diseases have been associated with gut microbiome abnormalities. The root cause of such diseases is not only due to bacterial dysbiosis, but also to change in bacterial functions...
ORGANISM(S): mouse gut metagenome 
2022-02-16 | PXD021932 | Pride
Mus musculus Taxonomy Metaproteomics Metagenome 
ProteomicsNovel insights into Strongyloides stercoralis third stage infective larvae proteome
Background - Strongyloidiasis is a neglected tropical disease affecting an estimated 600 million people, particularly in resource-limited settings. The infection can persist lifelong due to Strongyloides stercoralis peculiar auto-infective cycle. The cumbersome diagnosis and the limited knowledge of...
ORGANISM(S): Strongyloides stercoralis 
2023-03-11 | PXD037243 | Pride
Larvae Feces Strongyloides stercoralis Diagnosis Strongyloidiasis Proteome 
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