Sort   by:  
 Page size 
TranscriptomicsA genetically engineered ovarian cancer mouse model based on fallopian tube transformation mimics human high-grade serous carcinoma development
Recent evidence suggests that ovarian high-grade serous carcinoma (HGSC) originates from the epithelium of the fallopian tube. However, most mouse models are based on the previous prevailing view that ovarian cancer develops from the transformation of the ovarian surface epithelium. Here, we report ...
ORGANISM(S): Mus musculus 
2014-04-11 | E-GEOD-52011 | biostudies-arrayexpress
GenomicsHigh Grade Serous Ovarian Carcinomas Originate in the Fallopian Tube
High-grade serous ovarian carcinoma (HGSOC) is the most frequent type of ovarian cancer and has a poor outcome. It has been proposed that fallopian tube cancers may be precursors of HGSOC but evolutionary evidence for this hypothesis has been limited. To provide insights into the origins of HGSOC,...
EGAS00001002589 | EGA
ProteomicsFallopian tube lesions as potential precursors of early ovarian cancer: A comprehensive proteomic analysis.
The main goal of this study is to explore the proteomic expression in prophylactic salpingooophorectomy specimens, obtained from highly selected cohort of patients at risk of developing a high-grade serous ovarian carcinoma (HGSOC), because of a hereditary (BRCA 1 or 2 mutation) or a documented fami...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD020024 | Pride
Pre-neoplastic lesions Oavrian cancer Spatially resolved proteomics Ihc Proteomics 
ProteomicsEarly fallopian tube lesions and HGSC multiomics dataset
High-grade serous cancer (HGSC) of the ovary is the most common ovarian cancer subtype, typically diagnosed at late stages with a poor prognosis. Understanding early molecular events driving HGSC progression is crucial for developing effective detection strategies. We integrated spatial cell-type re...
ORGANISM(S): Homo sapiens (Human) 
2026-09-22 | PXD062349 | Pride
Fallopian tube cancer precursors Ovarian cancer Spatial multiomics Hgsc 
ProteomicsEarly fallopian tube lesions and HGSC spatial proteomics dataset
High-grade serous carcinoma (HGSC) is the most common ovarian cancer subtype, typically diagnosed at late stages with poor prognosis. Understanding early molecular events driving HGSC progression is crucial for early-stage cancer detection and development of effective treatment stategies. We perform...
ORGANISM(S): Homo sapiens (Human) 
2026-09-29 | PXD084823 | Pride
Fallopian tube cancer precursors Ovarian cancer Spatial proteomics Hgsc Stic (serous tubal intraepithelial carcinoma) 
UnknownMultimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma.
Not available
S-EPMC12130810 | biostudies-literature
ProteomicsSpatial proteomics of ovarian cancer precursors delineates early disease changes and drug targets
High-grade serous ovarian cancer (HGSOC) is often detected at an advanced stage, where curative treatment options are limited. Recent advances in ultrasensitive mass spectrometry-based spatial proteomics have provided a unique opportunity to uncover molecular drivers of early tumorigenesis and novel...
ORGANISM(S): Homo sapiens (Human) 
2025-10-19 | PXD069630 | Pride
Stic Fallopian tube Ovarian cancer 
GenomicsMultimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma
Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma
PRJNA1182712 | ENA
UnknownHigh grade serous ovarian carcinomas originate in the fallopian tube.
Not available
S-EPMC5653668 | biostudies-literature
UnknownFallopian tube lesions as potential precursors of early ovarian cancer: a comprehensive proteomic analysis.
Not available
S-EPMC10541450 | biostudies-literature
Sort   by:  
 Page size