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ProteomicsREV7 associates with ATRIP and FAM35A
REV7 is a remarkably multi-faceted protein with important and separable roles in multiple genome maintenance pathways including Trans-Lesion Synthesis, the Fanconi Anemia pathway, as well as p53 signaling and Double Stranded Break resection. To investigate novel functions and pathways involving REV7...
ORGANISM(S): Homo sapiens (Human) 
2026-01-22 | PXD072142 | Pride
Atrip Rev7 Fam35a 
UnknownFAM35A associates with REV7 and modulates DNA damage responses of normal and BRCA1-defective cells.
Not available
S-EPMC6003645 | biostudies-literature
UnknownSHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.
Not available
S-EPMC6138439 | biostudies-literature
UnknownGenetic association and functional analysis of rs7903456 in FAM35A gene and hyperuricemia: a population based study.
Not available
S-EPMC6018507 | biostudies-literature
ProteomicsShieldin complex promotes DNA end joining and counters homologous recombination in BRCA1-null cells
BRCA1 deficiencies cause breast, ovarian and other cancers, and render tumours hypersensitive to PARP-inhibitors. To understand resistance mechanisms, we conducted whole-genome CRISPR-Cas9 synthetic-viability/resistance screens in BRCA1-deficient breast cancer cells treated with PARP-inhibitors. Thu...
ORGANISM(S): Homo sapiens (Human) 
2018-05-31 | PXD009830 | Pride
C20orf196 Shieldin Fam35a 
GenomicsHomo sapiens
Shieldin complex promotes DNA end joining and counters homologous recombination in BRCA1-null cells: Immunoprecipitation-mass spectrometric analysis of protein interactors of GFP-C20orf196 and GFP-FAM35A
PRJNA471900 | ENA
UnknownAn OB-fold complex controls the repair pathways for DNA double-strand breaks.
Not available
S-EPMC6156606 | biostudies-literature
UnknownShieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells.
Not available
S-EPMC6145444 | biostudies-literature
UnknownGWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes.
Not available
S-EPMC5530361 | biostudies-literature
UnknownMultiple Membrane Transporters and Some Immune Regulatory Genes are Major Genetic Factors to Gout.
Not available
S-EPMC6062909 | biostudies-literature
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