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ProteomicsMAD2L2 dimerization and TRIP13 control shieldin activity in DNA repair
MAD2L2 (also known as REV7) functions in a diverse range of processes. It facilitates DNA lesion bypass through translesion synthesis (TLS), aids in interstrand crosslink repair and contributes to timely mitotic progression. Moreover, MAD2L2 plays an important role in DNA repair at DNA double strand...
ORGANISM(S): Homo sapiens (Human) 
2021-09-21 | PXD026912 | Pride
Mad2l2 Trip13 Dna repair Shieldin Nhej 
GenomicsShieldin complex whole-genome CRISPR screen
Shieldin complex promotes DNA end joining and counters homologous recombination in BRCA1-null cells
PRJEB26796 | ENA
ProteomicsShieldin complex promotes DNA end joining and counters homologous recombination in BRCA1-null cells
BRCA1 deficiencies cause breast, ovarian and other cancers, and render tumours hypersensitive to PARP-inhibitors. To understand resistance mechanisms, we conducted whole-genome CRISPR-Cas9 synthetic-viability/resistance screens in BRCA1-deficient breast cancer cells treated with PARP-inhibitors. Thu...
ORGANISM(S): Homo sapiens (Human) 
2018-05-31 | PXD009830 | Pride
C20orf196 Shieldin Fam35a 
Proteomics53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ
53BP1 governs a specialized, context-specific branch of the classical non-homologous end joining DNA double-strand break repair pathway. Mice lacking 53bp1 (also known as Trp53bp1) are immunodeficient owing to a complete loss of immunoglobulin class-switch recombination, and reduced fidelity of long...
ORGANISM(S): Mus musculus (Mouse) 
2018-07-26 | PXD009650 | Pride
Rev7 shieldin 
ProteomicsShieldin/CST-dependent and independent functions of 53BP1 control DNA end-joining and repair pathway choice
53BP1 regulates DNA end-joining in lymphocytes, diversifying immune antigen receptors. This involves nucleosome-bound 53BP1 at DNA double-stranded breaks (DSBs) recruiting RIF1 and shieldin, a poorly understood DNA-binding complex. The 53BP1-RIF1-shieldin axis is pathological in BRCA1-mutated cancer...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-27 | PXD045534 | Pride
Cst Shieldin Dna damage response 
UnknownThe shieldin complex mediates 53BP1-dependent DNA repair.
Not available
S-EPMC6141009 | biostudies-literature
UnknownShieldin complex assembly kinetics and DNA binding by SHLD3.
Not available
S-EPMC10082759 | biostudies-literature
UnknownMolecular basis for assembly of the shieldin complex and its implications for NHEJ.
Not available
S-EPMC7181697 | biostudies-literature
UnknownCCAR2 functions downstream of the Shieldin complex to promote double-strand break end-joining.
Not available
S-EPMC9894118 | biostudies-literature
UnknownDisassembly of the Shieldin Complex by TRIP13.
Not available
S-EPMC7480811 | biostudies-literature
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