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TranscriptomicsPyrococcus furiosus crRNAs associated with Cmr, Csa and Cst CRISPR-Cas systems
CRISPR-Cas immune systems function to defend prokaryotes against potentially harmful mobile genetic elements including viruses and plasmids. The multiple CRISPR-Cas systems (Types I, II, III) each recognize and target destruction of foreign invader nucleic acids via structurally and functionally div...
ORGANISM(S): Pyrococcus furiosus 
2015-07-10 | E-GEOD-65781 | biostudies-arrayexpress
ProteomicsCST interacts with the cohesin complex and promotes chromosome cohesion
Sister chromatid cohesion (SCC), the pairing of sister chromatids following DNA replication until mitosis, is established by loading of the cohesin complex on newly replicated chromatids. Cohesin must then be maintained until mitosis to prevent segregation defects and aneuploidy. However, how SCC is...
ORGANISM(S): Homo sapiens (Human) 
2021-07-28 | PXD026264 | Pride
Fork stalling Chromosome cohesion Cst Ctc1 Stn1 Cohesin Ten1 Dna replication 
GenomicsAnalysis by RNA-seq of the transcriptional profile of left ventricles of WT, CST-KO and CST-KO+CST treated mice
Analysis by RNA-seq of the transcriptional profile of left ventricles of WT, CST-KO and CST-KO+CST treated mice
PRJNA1283196 | ENA
GenomicsMycolicibacter kumamotonensis strain:CST 7247
Mycolicibacter kumamotonensis strain:CST 7247 Genome sequencing and assembly
PRJNA602726 | ENA
GenomicsCST in DSB repair
The CST complex mediates a post-resection non-homologous end-joining repair pathway and promotes local deletions in Saccharomyces cerevisiae
PRJEB88514 | ENA
ProteomicsShieldin/CST-dependent and independent functions of 53BP1 control DNA end-joining and repair pathway choice
53BP1 regulates DNA end-joining in lymphocytes, diversifying immune antigen receptors. This involves nucleosome-bound 53BP1 at DNA double-stranded breaks (DSBs) recruiting RIF1 and shieldin, a poorly understood DNA-binding complex. The 53BP1-RIF1-shieldin axis is pathological in BRCA1-mutated cancer...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-27 | PXD045534 | Pride
Cst Shieldin Dna damage response 
TranscriptomicsAnalysis by RNA-seq of the transcriptional profile of left ventricles of WT, CST-KO and CST-KO+CST treated mice
Hypertension is a critical risk factor for heart failure (HF), with metabolic inflexibility playing a pivotal role. Chromogranin A (CgA)-derived peptide Catestatin (CST: hCgA352-372) exerts hypotensive and cardioprotective effects, nonetheless CST’s effect on cardiac metabolism remains unexplored. O...
ORGANISM(S): Mus musculus 
2026-05-01 | GSE301063 | GEO
UnknownCST in maintaining genome stability: Beyond telomeres.
Not available
S-EPMC8081025 | biostudies-literature
UnknownStructure and function of the telomeric CST complex.
Not available
S-EPMC4872678 | biostudies-literature
GenomicsPyrococcus furiosus crRNAs associated with Cmr, Csa and Cst CRISPR-Cas systems
CRISPR-Cas immune systems function to defend prokaryotes against potentially harmful mobile genetic elements including viruses and plasmids. The multiple CRISPR-Cas systems (Types I, II, III) each recognize and target destruction of foreign invader nucleic acids via structurally and functionally div...
ORGANISM(S): Pyrococcus furiosus 
2015-07-10 | GSE65781 | GEO
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