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ProteomicsSTN1 facilitates metastasis by promoting transcription of EMT-activator ZEB1 in pancreatic cancer
As pancreatic ductal adenocarcinoma (PDAC) poses a formidable clinical challenge, demanding further exploration of its pathogenesis and drugs targeted for metastasis-the main cause of mortality. Here, we identified STN1, a CST complex member crucial for maintaining telomere lengths and genome stabil...
ORGANISM(S): Homo sapiens (Human) 
2025-08-05 | PXD062518 | Pride
Pancreatic cancer  stn1  stat3 
ProteomicsIdentification of STN1 interactiome in response to DNA damage in pancreatic cancer cells
STN1 is known to play a critical role in DNA damage response, however, the mechanisms by which this is performed, specifically in the context of pancreatic cancer are not well understood. Here we studied the changes in STN1 interactome in control and in the response to DNA-damage causing stimuli.
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD060475 | Pride
Ip-ms Dna-damage repair Stn1 Pancreatic cancer 
GenomicsSTN1 facilitates metastasis by promoting transcription of EMT-activator ZEB1 in pancreatic cancer
STN1 facilitates metastasis by promoting transcription of EMT-activator ZEB1 in pancreatic cancer
PRJNA1191384 | ENA
GenomicsEffect of STN1 knockdown on gene expression of PDAC cell lines
Effect of STN1 knockdown on gene expression of PDAC cell lines
PRJNA1072721 | ENA
GenomicsSTN1 facilitates metastasis by promoting transcription of EMT-activator ZEB1 in pancreatic cancer
As pancreatic ductal adenocarcinoma (PDAC) poses a formidable clinical challenge, demanding further exploration of its pathogenesis and drugs targeted for metastasis-the main cause of mortality. Here, we identified STN1, a CST complex member crucial for maintaining telomere lengths and genome stabil...
ORGANISM(S): Homo sapiens 
2025-05-18 | GSE282970 | GEO
UnknownSTN1-POLA2 interaction provides a basis for primase-pol α stimulation by human STN1.
Not available
S-EPMC5766158 | biostudies-literature
TranscriptomicsEffect of STN1 knockdown on gene expression of PDAC cell lines
We aimed to elucidate the mechanistic involvement of STN1 in facilitating the metastatic processes of PDAC. Utilizing RNA-seq profiling, we observed a substantial downregulation of the EMT pathway in PANC-1 cells with stable STN1 knockdown
ORGANISM(S): Homo sapiens 
2024-12-31 | GSE254968 | GEO
GenomicsThe telomeric Cdc13-Stn1-Ten1 complex regulates RNA pol II transcription
The telomeric Cdc13-Stn1-Ten1 complex regulates RNA pol II transcription
PRJNA492453 | ENA
UnknownKRAS-induced STN1 (OBFC1) promotes proper CTC1-STN1-TEN1 complex-independent DNA double-strand break repair and cell cycle checkpoint maintenance in pancreatic cancer.
Not available
S-EPMC12489472 | biostudies-literature
UnknownSTN1 protects chromosome ends in Arabidopsis thaliana.
Not available
S-EPMC2604966 | biostudies-literature
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