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ProteomicsMAD2L2 dimerization and TRIP13 control shieldin activity in DNA repair
MAD2L2 (also known as REV7) functions in a diverse range of processes. It facilitates DNA lesion bypass through translesion synthesis (TLS), aids in interstrand crosslink repair and contributes to timely mitotic progression. Moreover, MAD2L2 plays an important role in DNA repair at DNA double strand...
ORGANISM(S): Homo sapiens (Human) 
2021-09-21 | PXD026912 | Pride
Mad2l2 Trip13 Dna repair Shieldin Nhej 
GenomicsExpression data from T24 cells after TRIP13 knockdown
Expression data from T24 cells after TRIP13 knockdown
PRJNA429447 | ENA
GenomicsRNA-seq analysis of transcriptomic changes in TRIP13-deficient MOLM-13 leukemia cells
RNA-seq analysis of transcriptomic changes in TRIP13-deficient MOLM-13 leukemia cells
PRJNA1328614 | ENA
TranscriptomicsExpression data from T24 cells after TRIP13 knockdown
TRIP13 is a crucial regulator of double-stranded break repair and spindle apparatus checkpoint and its abnormal expression has been found in several human cancers, whereas the role of TRIP13 in the malignant development of urothelial bladder cancer has not been fully elucidated. We used microarrays ...
ORGANISM(S): Homo sapiens 
2019-01-10 | GSE109029 | GEO
GenomicsThe effect of TRIP13 on glioma cell function and signaling pathways
The effect of TRIP13 on glioma cell function and signaling pathways
PRJNA593736 | ENA
GenomicsTRIP13 Promotes the Expansion and Immunosuppression of CD4+Foxp3+ Regulatory T Cells by Sustaining HAT1 Stability
TRIP13 Promotes the Expansion and Immunosuppression of CD4+Foxp3+ Regulatory T Cells by Sustaining HAT1 Stability
PRJNA1303721 | ENA
TranscriptomicsRNA-seq analysis of transcriptomic changes in TRIP13-deficient MOLM-13 leukemia cells
We performed RNA-seq on MOLM-13 acute myeloid leukemia cells with TRIP13 knockdown to investigate the transcriptomic changes associated with this cancer-testis gene. TRIP13 is essential for AML progression but dispensable for normal hematopoiesis. Its activation reprograms cellular metabolism from g...
ORGANISM(S): Homo sapiens 
2026-09-10 | GSE308030 | GEO
TranscriptomicsTRIP13 Promotes the Expansion and Immunosuppression of CD4+Foxp3+ Regulatory T Cells by Sustaining HAT1 Stability
There is compelling evidence that TNF preferentially activates and expands CD4+Foxp3+ regulatory T cells (Tregs) through TNFR2. However, the precise mechanisms underlying TNF-TNFR2 pathway-mediated Treg proliferation remain to be fully elucidated. In this study, using RNA-seq profiling of TNFR2+ and...
ORGANISM(S): Mus musculus 
2026-08-01 | GSE305021 | GEO
UnknownTRIP13: A promising cancer immunotherapy target.
Not available
S-EPMC11467489 | biostudies-literature
TranscriptomicsThe effect of TRIP13 on glioma cell function and signaling pathways
To gain insight into the molecular mechanisms underlying TRIP13-mediated oncogenic activity in GBM, we performed RNA-seq on spheres derived from U87MG-shTRIP13 and control cells .This analysis identified 1094 genes whose expression was markedly reduced by TRIP13 knockdown in U87MG-derived spheres (f...
ORGANISM(S): Homo sapiens 
2019-12-06 | GSE141510 | GEO
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