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GenomicsDNA methylation is stable after MMEJ and NHEJ double strand break repair
DNA double strand breaks (DSBs) are a major source of mutations. Both non-homologous-end-joining (NHEJ) and microhomology-mediated-end-joining (MMEJ) DSB repair pathways are error prone and produce deletions, which can lead to cancer. DSBs also lead to epigenetic changes, including demethylation, wh...
ORGANISM(S): Homo sapiens 
2022-09-11 | E-MTAB-12037 | biostudies-arrayexpress
GenomicsDNA Methylation is stable after MMEJ and NHEJ double strand break repair - OCI-AML3 dataset
DNA double strand breaks (DSBs) are a major source of mutations. Both non-homologous-end-joining (NHEJ) and microhomology-mediated-end-joining (MMEJ) DSB repair pathways are error prone and produce deletions, which can lead to cancer. DSBs also lead to epigenetic changes, including demethylation, wh...
ORGANISM(S): Homo sapiens 
2022-08-25 | E-MTAB-12061 | biostudies-arrayexpress
ProteomicsProteomic analysis of DNA synthesis on a structured DNA template in human cellular extracts: Interplay between NHEJ and replication-associated proteins
It has been established that short inverted repeats (SIRs) trigger base substitution mutagenesis in human cells. However, how the replication machinery deals with this structured DNA is unknown. We have previously reported that in human cell-free extracts, DNA primer extension using a structured sin...
ORGANISM(S): Homo sapiens (Human) 
2020-02-04 | PXD011156 | Pride
Dna replication Short inverted repeats Nhej 
GenomicsTranscriptomics reveals the role of NHEJ in mycobacterial antiphage defense
Transcriptomics reveals the role of NHEJ in mycobacterial antiphage defense
PRJNA1395048 | ENA
ProteomicsUFMylation orchestrates chromatin engagement of core NHEJ components to promote DNA double-strand break repair
DNA double-strand breaks (DSBs) are highly cytotoxic lesions that – if misrepaired – can lead to genomic instability, cancer, and developmental disorders. While ubiquitin and select ubiquitin-like proteins (UBLs) are established regulators of DSB repair, many UBLs remain understudied. Here, through ...
ORGANISM(S): Homo sapiens (Human) 
2026-07-31 | PXD069185 | Pride
Double-strand break Proximity proteomics Ufmylation Nhej 
TranscriptomicsTranscriptomics reveals the role of NHEJ in mycobacterial antiphage defense
In the ongoing arms race with phages, bacteria have evolved diverse defense systems, such as CRISPR-Cas and restriction-modification systems. The DNA double-strand break (DSB) repair system represents a core mechanism for maintaining genomic integrity and is vital for cell survival. However, it rema...
ORGANISM(S): Mycolicibacterium smegmatis 
2026-01-01 | GSE315142 | GEO
ProteomicsPC4-mediated Ku PARylation facilitates NHEJ-dependent DNA damage repair
Radiotherapy is one of the mainstays for the treatment of hepatocellular carcinoma (HCC); however, a substantial fraction of HCC patients develops radioresistance and eventually suffer from tumour progression or relapse, a major impediment to the use of radiotherapy. One of the main goals in HCC man...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042218 | Pride
Pc4 Ms Liver cancer 
GenomicsTranscriptome changes of Hela cells with blocking classical and alternative non-homologous end-joining (NHEJ) pathways
Transcriptome changes of Hela cells with blocking classical and alternative non-homologous end-joining (NHEJ) pathways
PRJNA558142 | ENA
GenomicsDNA methylation is stable after MMEJ and NHEJ double strand break repair
DNA methylation is stable after MMEJ and NHEJ double strand break repair
PRJEB55333 | ENA
ProteomicsPAXX is an accessory c-NHEJ factor that associates with Ku70 and has overlapping functions with XLF
In mammalian cells, classical non-homologous end joining (c-NHEJ) is critical for DNA double-strand break repair induced by ionizing radiation and during V(D)J recombination in developing B and T lymphocytes. Recently, PAXX was identified as a new c-NHEJ core component. We report here, that PAXX-def...
ORGANISM(S): Homo sapiens (Human) 
2016-10-06 | PXD004659 | Pride
Non-homologous end joining Micro-homology mediated end joining V(d)j recombination Genomic instability Dna double-strand break 
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