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ProteomicsKAT5-mediated acetylation of PC4 facilitates DNA repair by promoting chromatin reorganization
Human positive coactivator 4 (PC4), is a highly abundant non-histone chromatin protein involved in diverse cellular processes, including transcription regulation, genome organization, autophagy, B-cell differentiation, neurogenesis, DNA repair, etc. Most PC4 is phosphorylated in cells, which interac...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD059878 | Pride
Non-histone chromatin protein Lysine acetyltransferases (kats) Positive coactivator 4 (pc4) Dna damage Atomic force microscopy (afm) 
ProteomicsPC4-IP complex in Huh7 cells during G1 and G2 phases
Numerous genes exhibit periodic oscillations in mRNA expression, essential for orderly cell division. Mitosis-related mRNAs fluctuate cyclically from the G2 to M phase, primarily regulated by transcription factors. However, the role of post-transcriptional regulation in this process remains unclear....
ORGANISM(S): Homo sapiens (Human) 
2025-01-31 | PXD052566 | Pride
Pc4 Huh7 G2 phase G1 phase 
ProteomicsPC4-mediated Ku PARylation facilitates NHEJ-dependent DNA damage repair
Radiotherapy is one of the mainstays for the treatment of hepatocellular carcinoma (HCC); however, a substantial fraction of HCC patients develops radioresistance and eventually suffer from tumour progression or relapse, a major impediment to the use of radiotherapy. One of the main goals in HCC man...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042218 | Pride
Pc4 Ms Liver cancer 
ProteomicsKAT5-mediated acetylation of PC4 facilitates DNA repair by promoting chromatin reorganization
Human positive coactivator 4 (PC4), is a highly abundant non-histone chromatin protein involved in diverse cellular processes, including transcription regulation, genome organization, autophagy, B-cell differentiation, neurogenesis, DNA repair, etc. Most PC4 is phosphorylated in cells, which interac...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD058855 | Pride
Non-histone chromatin protein Lysine acetyltransferases (kats) Positive coactivator 4 (pc4) Dna damage Atomic force microscopy (afm) 
GenomicsGenome-wide DNA accessibility mapping using ATAC-seq in HEK293 in vector control, PC4 knockdown and PC4 phosphorylation specific mutant and mimic
Genome-wide DNA accessibility mapping using ATAC-seq in HEK293 in vector control, PC4 knockdown and PC4 phosphorylation specific mutant and mimic
PRJNA790998 | ENA
GenomicsGenome-wide DNA accessibility mapping using ATAC-seq in HEK293 in vector control, PC4 knockdown and PC4 phosphorylation specific mutant and mimic
To assess the mechanisms by which PC4 mediates chromatin compaction in cells and regulation of genome organization by its phosphorylation state, we measured the chromatin accessibility landscape using ATAC-seq of vector control 293 cells (Control/shNS), PC4 knockdown (KD/PC4 KD) and upon ectopic exp...
ORGANISM(S): Homo sapiens 
2022-05-12 | GSE191333 | GEO
ProteomicsPC4 is a post-transcriptional manipulator of D-type cyclins and centromere proteins
The cell cycle is an intensively control process, in which cell-cycle proteins display a cyclical expression pattern regulated by specific transcription, translation and degradation. Cell cycle progression is initiated by highly expressed D-type cyclins (D1/2/3) to facilitate DNA synthesis, subseque...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-02-03 | PXD033637 | Pride
Pc4 Ptm Cell cycle Rbp 
TranscriptomicsRNA sequencing analysis in WT and Pc4-OE mESC lines.
Spermatogonial stem cells (SSCs) can spontaneously dedifferentiate into embryonic stem cell (ESC)-like cells, which are designated as multipotent SSCs (mSSCs), without ectopic expression of reprogramming factors. SSCs express key OSKM reprogramming factors at some levels, and do not require ectopic ...
ORGANISM(S): Mus musculus 
2015-10-30 | E-GEOD-74149 | biostudies-arrayexpress
GenomicsChromatin Protein PC4 Orchestrates B Cell Differentiation by Collaborating with IKAROS and IRF4 (RRBS)
Chromatin Protein PC4 Orchestrates B Cell Differentiation by Collaborating with IKAROS and IRF4 (RRBS)
PRJNA685217 | ENA
GenomicsPC4 is a post-transcriptional manipulator of D-type cyclins and centromere proteins (eCLIP-Seq).
PC4 is a post-transcriptional manipulator of D-type cyclins and centromere proteins (eCLIP-Seq).
PRJNA835851 | ENA
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