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ProteomicsThe non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma
FAM46C is one of the most frequently mutated genes in multiple myeloma (MM). Here, using a combination of in vitro and in vivo approaches, we demonstrate that FAM46C encodes an active non-canonical poly(A) polymerase which enhances mRNA stability and gene expression. Reintroduction of active FAM46C ...
ORGANISM(S): Homo sapiens (Human) 
2018-03-09 | PXD006790 | Pride
Lc-msms Fam46c Anemia Mouse B lymphocytes Polyadenylation Multiple myeloma 
TranscriptomicsSequencing of RNAs derived from the purified endoplasmic reticulum of human LP1 myeloma cells expressing either the wt FAM46C protein or the D90G mutant allele
Endoplasmic reticula (ER) were isolated from LP1 human myeloma cells expressing either the wt FAM46C protein or the D90G mutant version, which is often found in myeloma patients. RNAs were purified from the ER and sequenced. Quantitation and characterization of specifically ER-bound mRNAs is importa...
ORGANISM(S): Homo sapiens 
2020-10-22 | E-MTAB-8497 | biostudies-arrayexpress
ProteomicsFAM46C is an IFN stimulated gene that restricts lentiviral particle production by modulating autophagy
FAM46C is a multiple myeloma tumour suppressor whose function is only starting to be elucidated. We recently showed that in multiple myeloma cells FAM46C triggers apoptosis by inhibiting autophagy and altering intracellular trafficking and protein secretion. To date, both a physiological characteriz...
ORGANISM(S): Homo sapiens (Human) 
2023-06-19 | PXD036818 | Pride
Fam46c inhibits lentiviral production 
TranscriptomicsMicroarray of the multiple myeloma OPM2 cell line expressing either wt FAM46C or the FAM46C-D90G mutant allele
The aim of the analysis is to compare the trascriptome of myeloma cells expressing the wt version of novel oncosuppressor FAM46C comparing it with that of cells expressing a mutant variant of the same gene often found in patients (the D90G mutant allele) or to a Mock control. Cells were grown in RP...
ORGANISM(S): Homo sapiens 
2020-10-23 | E-MTAB-8188 | biostudies-arrayexpress
GenomicsThe non-canonical poly(A) polymerase FAM46C promotes erythropoiesis [ADAR_APOBEC]
The non-canonical poly(A) polymerase FAM46C promotes erythropoiesis [ADAR_APOBEC]
PRJNA1029583 | ENA
GenomicsThe non-canonical poly(A) polymerase FAM46C promotes erythropoiesis [RIP]
The non-canonical poly(A) polymerase FAM46C promotes erythropoiesis [RIP]
PRJNA1029586 | ENA
TranscriptomicsThe role of FAM46C in myeloma cells [sequencing]
FAM46C is one of the most recurrently mutated genes in multiple myeloma (MM), however its role in disease pathogenesis is not determined. Here we demonstrate that wild type (WT) FAM46C overexpression induces substantial cytotoxicity in MM cells. In contrast, FAM46C mutations found in MM patients abr...
ORGANISM(S): Homo sapiens 
2017-07-26 | GSE99356 | GEO
TranscriptomicsThe role of FAM46C in myeloma cells [array]
FAM46C is one of the most recurrently mutated genes in multiple myeloma (MM), however its role in disease pathogenesis is not determined. Here we demonstrate that wild type (WT) FAM46C overexpression induces substantial cytotoxicity in MM cells. In contrast, FAM46C mutations found in MM patients abr...
ORGANISM(S): Homo sapiens 
2017-07-26 | GSE99357 | GEO
UnknownStructural and Functional Analyses of the FAM46C/Plk4 Complex.
Not available
S-EPMC7415566 | biostudies-literature
GenomicsThe non-canonical poly(A) polymerase FAM46C promotes erythropoiesis [Capture-C]
The non-canonical poly(A) polymerase FAM46C promotes erythropoiesis [Capture-C]
PRJNA1029582 | ENA
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