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TranscriptomicsMicroarray analysis of gene expression changes in human A549 lung cancer cells upon siRNA knockdown of FAM60A and SDS3
The Sin3 histone deacetylase (HDAC) complex is a 1.2 MDa chromatin modifying complex that can repress transcription by binding to gene promoters and deacetylating histones. The Sin3/HDAC complex can affect cell cycle progression through multiple mechanisms and is among the targets of anticancer dru...
ORGANISM(S): Homo sapiens 
2012-09-15 | E-GEOD-39733 | biostudies-arrayexpress
ProteomicsSIN3A Acetylation Complex - Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal
Sin3a is the central scaffold protein of the prototypical Hdac1/2 chromatin repressor complex, crucially required during early embryonic development for the growth of pluripotent cells of the inner cell mass. Here, we explore the endogenous composition of the Sin3a-Hdac complex in pluripotent embryo...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-05-19 | PXD005464 | Pride
Self-renewal Sin3a complex Embryonic stem cell Fam60a 
ProteomicsLoss of FAM60A disrupts Sin3/HDAC control of the Hippo signaling and promotes oncogenic YAP1 activation
FAM60A, a Sin3/HDAC subunit with defined chromatin roles, has broader functions unveiled here. Integrating immunological, biochemical, CRISPR/Cas9, genomic and proteomic analyses, we mapped the FAM60A interaction network. Proteomic profiling revealed direct binding to HDAC1 and associations with RNA...
ORGANISM(S): Homo sapiens (Human) 
2026-05-01 | PXD066554 | Pride
Halo-tag Lc-ms Fam60a 
GenomicsExpression data from PTC cell lines transfected with FAM60A-shRNA
Expression data from PTC cell lines transfected with FAM60A-shRNA
PRJNA645900 | ENA
GenomicsFam60a defines a embryonic stem cell specific Sin3a/Hdac complex.
ChIP coupled with NGS identifies genome-wide binding sites of a ES cells specific Sin3a/Hdac complex. The aim of these experiments is to study the role of Fam60a in the Sin3a/Hdac complex. ChIP-Seq experiments reveal that Fam60a is required to maintain high levels of Sin3a binding on target genes in...
ORGANISM(S): Mus musculus 
2017-04-24 | GSE81081 | GEO
GenomicsLoss of FAM60A disrupts Sin3/HDAC control of the Hippo signaling and promotes oncogenic YAP1 activation
Loss of FAM60A disrupts Sin3/HDAC control of the Hippo signaling and promotes oncogenic YAP1 activation
PRJNA1066377 | ENA
UnknownLoss of FAM60A attenuates cell proliferation in glioma via suppression of PI3K/Akt/mTOR signaling pathways.
Not available
S-EPMC8363885 | biostudies-literature
TranscriptomicsLoss of FAM60A disrupts Sin3/HDAC control of the Hippo signaling and promotes oncogenic YAP1 activation
FAM60A (also known as SINHCAF) is a subunit of the Sin3/HDAC histone deacetylase complex with established roles in chromatin remodeling, yet its broader cellular functions remain largely undefined. Using immunological, biochemical, CRISPR/Cas9, genomic, and proteomic approaches, we mapped the FAM60A...
ORGANISM(S): Homo sapiens 
2026-04-30 | GSE253631 | GEO
UnknownFAM60A promotes proliferation and invasion of colorectal cancer cells by regulating the Wnt/β-catenin signaling pathway.
Not available
S-EPMC11912056 | biostudies-literature
TranscriptomicsExpression data from PTC cell lines transfected with FAM60A-shRNA
The mRNA and protein levels of FAM60A were significantly upregulated in PTC cancer tissues compared with paired normal tissue. Knockdown of FAM60A1 in TPC-1 and K1 significantly supressed cell growth, colony formation ability, tumor invasion, and phase transition of the cell cycle. We used microarra...
ORGANISM(S): Homo sapiens 
2020-11-26 | GSE154331 | GEO
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