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GenomicsRapid transcription of arc/arg3.1 and other very fast immediate early genes in response to neuronal activity is mediated by a stalled RNA polymerase II mechanism
Transcription of immediate early genes (IEGs) in neurons is exquisitely sensitive to neuronal activity, but the mechanism underlying the earliest of these transcription events is largely unknown. Here we demonstrate that very fast IEGs (VF-IEGs) such as arc/arg3.1 are poised for rapid transcription ...
ORGANISM(S): Rattus norvegicus 
2011-05-24 | E-GEOD-22878 | biostudies-arrayexpress
TranscriptomicsUpstream Anti-sense Promoters Act as Local Enhancers of Mammalian Protein-coding Genes
Anti-sense transcription originating upstream of mammalian protein-coding genes is a well-documented phenomenon, but remarkably little is known about the function or regulation of these anti-sense promoters or the non-coding RNAs they generate. Here we define at nucleotide resolution the divergent t...
ORGANISM(S): Mus musculus 
2015-06-23 | E-GEOD-62151 | biostudies-arrayexpress
GenomicsGlobal Analysis of Short RNAs Reveals Widespread Promoter-Proximal Stalling and Arrest of Pol II
We developed a novel approach to isolate and characterize, at nucleotide-level resolution, the RNAs derived from RNA polymerase II (Pol II) in early elongation complexes. We find that high numbers of these short RNAs are not correlated with gene expression but instead are indicative of promoter-prox...
ORGANISM(S): Drosophila melanogaster 
2009-12-11 | E-GEOD-18643 | biostudies-arrayexpress
TranscriptomicsPost-transcriptional regulation of cell-cell interaction protein-encoding transcripts by Zfs1p in S. pombe (RNA-Seq)
Members of the tristetraprolin (TTP) family of CCCH tandem zinc finger proteins can bind directly to AU-rich elements in mRNAs and promote transcript deadenylation and decay. The yeast Schizosaccharomyces pombe expresses a single TTP family member, Zfs1p, that has been linked to the mating response...
ORGANISM(S): Schizosaccharomyces pombe 
2012-11-06 | E-GEOD-35376 | biostudies-arrayexpress
TranscriptomicsPost-transcriptional regulation of cell-cell interaction protein-encoding transcripts by Zfs1p in S. pombe
Members of the tristetraprolin (TTP) family of CCCH tandem zinc finger proteins can bind directly to AU-rich elements in mRNAs and promote transcript deadenylation and decay. The yeast Schizosaccharomyces pombe expresses a single TTP family member, Zfs1p, that has been linked to the mating response...
ORGANISM(S): Schizosaccharomyces pombe 
2012-11-06 | E-GEOD-35009 | biostudies-arrayexpress
GenomicsInterrelationships between replication infidelity and genome composition
An enduring issue in evolutionary and cancer biology is how replication infidelity influences genome composition and vice versa. Here we examine this issue by sequencing the genomes of diploid budding yeast strains that are either mismatch repair (MMR) proficient or deficient and encode wild type or...
ORGANISM(S): Saccharomyces cerevisiae 
2014-08-25 | E-GEOD-56939 | biostudies-arrayexpress
UnknownCharacterization of genetic variation in the VGLL4 gene in anorexia nervosa.
Not available
S-EPMC4104366 | biostudies-literature
UnknownEvidence for the role of EPHX2 gene variants in anorexia nervosa.
Not available
S-EPMC3852189 | biostudies-literature
UnknownDissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors.
Not available
S-EPMC8851871 | biostudies-literature
UnknownGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Not available
S-EPMC4835977 | biostudies-literature
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