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UnknownInhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface.
Not available
S-EPMC4822621 | biostudies-literature
TranscriptomicsGene expression profiling of HOS (human osteosarcoma) cells exposed to fluoride
Though fluoride is considered an essential trace element, chronic exposure to fluoride is known to cause toxic effects. Chronic exposure of high concentration of fluoride may leads to fluorosis. To understand the molecular mechanism of fluoride induced toxicity gene expression profiling was performe...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-70719 | biostudies-arrayexpress
UnknownA Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases.
Not available
S-EPMC6415690 | biostudies-literature
TranscriptomicsMNNG/HOS cells and sarcospheres
This SuperSeries is composed of the following subset Series: GSE38133: TGF-beta1 effect on human osteosarcoma cell line MNNG/HOS GSE38134: Expression analysis of human osteosarcoma cell line MNNG/HOS sarcospheres, hypoxia-induced sarcospheres and TGF-beta1-induced sarcospheres Refer to individual Se...
ORGANISM(S): Homo sapiens 
2012-05-22 | E-GEOD-38135 | biostudies-arrayexpress
TranscriptomicsTGF-beta1 effect on human osteosarcoma cell line MNNG/HOS
Investigation of whole genome gene expression level changes in human osteosarcoma cell line MNNG/HOS treated by TGF-beta1 for three days (mesophase) and five days (sarcospheres iOSCs), compared to non-treatment cells (residual adherent cells). A three chip study using total RNA cover from three cult...
ORGANISM(S): Homo sapiens 
2012-05-22 | E-GEOD-38133 | biostudies-arrayexpress
TranscriptomicsExpression analysis of human osteosarcoma cell line MNNG/HOS sarcospheres, hypoxia-induced sarcospheres and TGF-beta1-induced sarcospheres
Invastigation of whole genome gene expression level changes in human osteosarcoma cell line MNNG/HOS sarcospheres,hypoxia-induced sarcospheres and TGF-beta1 induced sarcospheres. A three chip study using total RNA cover from three cultures of human osteosarcoma cell line MNNG/HOS sarcospheres, hypo...
ORGANISM(S): Homo sapiens 
2012-05-22 | E-GEOD-38134 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of human osteosarcoma cell lines to identify microaberrations
Background: Osteosarcoma (OS) is a very aggressive bone tumor characterized by highly abnormal complex karyotypes. With the improved resolution offered by array comparative genomic hybridization (array CGH) platforms, it is possible to readily detect cryptic microaberrations in genomic DNA. The i...
ORGANISM(S): Homo sapiens 
2008-06-18 | E-GEOD-7077 | biostudies-arrayexpress
TranscriptomicsmiRNA expression profile in HOS cells exposed to sodium fluoride
Fluorosis is caused due to excess of fluoride intake over a long period of time. Aberrant change in RUNX2-mediated signaling cascade is one of the decisive steps during the pathogenesis of fluorosis. Till date, role of fluoride on the epigenetic alterations is not studied. In the present study, glob...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-57550 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of human HOS cell line differentiated by beta-glycerophosphate (BGP) treatment
Human HOS cell line was differentiated by beta-glycerophosphate (BGP) treatment and gene expression profiling was studied with Illumina expression microarray (HumanHT12_V4). Three negative control replicates vs. three BGP 3-day treatment replicates
ORGANISM(S): Homo sapiens 
2016-04-07 | E-GEOD-68012 | biostudies-arrayexpress
ProteomicsA High-resolution Systems-wide Screen for Substrates of the SCFβTrCP Ubiquitin Ligase - reproducibility evaluation
This project demonstrates a combined bioinformatics and affinity purification-mass spectrometry (AP-MS) workflow for identifying in a systems-wide manner bone fide substrates of βTrCP
ORGANISM(S): Homo sapiens (Human) 
2015-01-06 | PXD001224 | Pride
Ap-ms Perseus Interaction proteomics Βtrcp Crapome Ubiquitin e3 ligase Fbw11 
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