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TranscriptomicsTranscription profiling of Drosophila Hr39 mutant females reveals the sf1-related nuclear hormone receptor hr39 regulates Drosophila female reproductive tract development and function
The vertebrate nuclear hormone receptor steroidogenic factor 1 (SF1; NR5A1) controls reproductive development and regulates the transcription of steroid-modifying cytochrome P450 genes. We find that the SF1-related Drosophila nuclear hormone receptor HR39 is also essential for sexual development. In...
ORGANISM(S): Drosophila melanogaster 
2008-06-11 | E-GEOD-10264 | biostudies-arrayexpress
TranscriptomicsUnexpected Inflammatory Effects of Intravaginal Gels (Universal Placebo Gel and Nonoxynol-9) on the Upper Female Reproductive Tract: an Experimental Crossover Study
Intravaginal HIV microbicides could provide women with a self-controlled means for HIV prevention, but results from clinical trials have been largely disappointing. We postulated that unrecognized effects of intravaginal gels on the upper female reproductive tract (FRT) might contribute to the lower...
ORGANISM(S): Homo sapiens 
2015-08-10 | E-GEOD-58090 | biostudies-arrayexpress
MetabolomicsFecal metabolites in sows of different reproductive potential

Placental dysplasia critically impairs fetal growth and development by disrupting nutrient supply. Thiamine, predominantly in its bioactive form thiamine pyrophosphate, serves as an essential coenzyme in mitochondrial energy metabolism, yet its regulatory role in placental development remains elu...

2025-07-29 | MTBLS12795 | MetaboLights
ProteomicsComparison of post-mating responses in the female reproductive tract among Drosophila species
Fertility depends on the coordination of complex interactions between male and female reproductive proteins inside the female reproductive tract (FRT). These interactions mediate a suite of changes in female behavior, morphology, and physiology after mating, yet little is known about how the molecul...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2020-06-25 | PXD017730 | Pride
Female reproductive tract Lc-m Post-mating responses Drosophila melanogaster 
ProteomicsProteomic differences between Drosophila melanogaster female reproductive tract tissue and fluid and their postmating responses
Fertility depends on the progression of complex and coordinated postmating processes within the extracellular luminal environment of the female reproductive tract (FRT). To achieve a more comprehensive level of knowledge regarding female-derived proteins available to interact with the ejaculate, we ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-09-22 | PXD025085 | Pride
Drosophila Reproductoin Ejaculate-female interaction 
ProteomicsThe life history of Drosophila sperm depends on molecular continuity between male and female reproductive tracts: heavy-female isotopic labeling to estimate abundances of female-derived sperm protein
Interactions between sperm and the female reproductive tract (FRT) are critical to fertility, but knowledge of the molecular mechanisms by which the FRT interacts with sperm and influences sperm fate remains limited. Here, we used sex-specific isotopic labeling to estimate the relative abundance of ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-03-14 | PXD027806 | Pride
Lc-msms Female reproductive tract Fertility Sperm Silac Drosophila melanogaster 
ProteomicsThe life history of Drosophila sperm depends on molecular continuity between male and female reproductive tracts
Interactions between sperm and the female reproductive tract (FRT) are critical to fertility, but knowledge of the molecular mechanisms by which the FRT interacts with sperm and influences sperm fate remains limited. Here, we used whole-cell quantitative proteomics to track the protein composition o...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-03-14 | PXD027807 | Pride
Lc-msms Female reproductive tract Fertility Sperm Drosophila melanogaster 
ProteomicsThe life history of Drosophila sperm depends on molecular continuity between male and female reproductive tracts: heavy-male isotopic labeling to identify female-derived sperm proteins
Interactions between sperm and the female reproductive tract (FRT) are critical to fertility, but knowledge of the molecular mechanisms by which the FRT interacts with sperm and influences sperm fate remains limited. Here, we used sex-specific isotopic labeling to identify female-derived proteins th...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-03-11 | PXD027802 | Pride
Lc-msms Female reproductive tract Fertility Sperm Silac Drosophila melanogaster 
ProteomicsQuantitative proteomics reveals rapid divergence in the postmating response of female reproductive tracts among sibling species
Fertility depends, in part, on interactions between male and female reproductive proteins inside the female reproductive tract (FRT) that mediate postmating changes in female behavior, morphology, and physiology. Coevolution between interacting proteins within species may drive reproductive incompat...
ORGANISM(S): Drosophila simulans Drosophila mauritiana 
2020-06-25 | PXD017708 | Pride
Drosophila simulans Lc-msms Female reproductive tract Tmt Drosophila mauritiana 
TranscriptomicsTranscription profiling of Drosophila mated females to identify mating response genes
Male-derived accessory gland proteins (Acps) that are transferred to females during mating have profound effects on female reproductive physiology including increased ovulation, mating inhibition, and effects on sperm utilization and storage. The extreme rates of evolution seen in Acps may be driven...
ORGANISM(S): Drosophila melanogaster 
2008-06-13 | E-GEOD-5012 | biostudies-arrayexpress
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