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ProteomicsA Kinetic Scout Approach Accelerates Targeted Protein Degrader Discovery
Bifunctional molecules such as targeted protein degraders induce proximity to promote gain-of-function pharmacology. These powerful approaches have gained broad traction across academia and the pharmaceutical industry, leading to an intensive focus on strategies that can accelerate their identificat...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD055398 | Pride
Targeted protein degradation Protac Degraders Kinase Vhl Ubiquitin Kinetics 
ProteomicsA Kinetic Scout Approach Accelerates Targeted Protein Degrader Discovery
Bifunctional molecules such as targeted protein degraders induce proximity to promote gain-of-function pharmacology. These powerful approaches have gained broad traction across academia and the pharmaceutical industry, leading to an intensive focus on strategies that can accelerate their identificat...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD055399 | Pride
Targeted protein degradation Protac Degraders Kinase Vhl Ubiquitin Kinetics 
UnknownInterprofessional communication in medical simulation: findings from a scoping review and implications for academic medicine.
Not available
S-EPMC8962252 | biostudies-literature
TranscriptomicsRNA-seq comparison of fetal lung and cultured fetal lung derived organoids with pluripotent stem cell derived lung organoids
Underdeveloped lungs are the primary cause of death in premature infants, however, little is known about stem and progenitor cell maintenance during human lung development. In this study, we have identified that FGF7, Retinoic Acid and CHIR-99021, a small molecule that inhibits GSK3 to activate Wnt ...
ORGANISM(S): Homo sapiens 
2018-11-17 | E-MTAB-6023 | biostudies-arrayexpress
TranscriptomicsProfiling of Human Adipose Tissue and Effect of Sibutramine on Gene Expression
We analyzed the expression of 23,653 transcripts in the adipose tissue of 19 individuals treated with Sibutramine Keywords: sibutramine effect 157 adipose tissue samples from 19 individuals treated with sibutramin as well as placebo were profiled for gene expression.
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-10545 | biostudies-arrayexpress
UnknownAbdominal infections in the intensive care unit: characteristics, treatment and determinants of outcome.
Not available
S-EPMC4122779 | biostudies-literature
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