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MetabolomicsCitrate serves as a signal molecule to modulate carbon metabolism and iron homeostasis in Staphylococcus aureus

Pathogenic bacteria's metabolic adaptation for survival and proliferation within hosts is a crucial aspect of bacterial pathogenesis. Here, we demonstrate that citrate, the first intermediate of the tricarboxylic acid (TCA) cycle, plays a key role as a regulator of gene expression in Staphylococc...

2024-04-26 | MTBLS4276 | MetaboLights
TranscriptomicsTranscription profiling of Bacillus subtilis wild type and yvcJ strains during the competence transition phase
Competence experiments were carried out in MD medium containing 10.7 g/l K2HPO4, 6 g/l KH2PO4, 1g/l trisodium citrate - 5H2O, 2% (w/v) glucose, 50 mg/l L-Trp, 11 mg/l ferric ammonium citrate, 2.5 g/l potassium aspartate et 3 mM MgS04. Wt and yvcJ strain were cultured in this medium until transition ...
ORGANISM(S): Bacillus subtilis 
2008-12-09 | E-MEXP-1471 | biostudies-arrayexpress
ProteomicsLFQ DIA to analyze the proteome of NPC mutant iNeurons with and without ferric ammonium citrate
Label-free quantification (LFQ) using data-independent acquisition (DIA) on the Orbitrap Astral was performed to analyze the proteome of iNeurons with NPC1 and NPC2 knocked out. The experiment includes the following time points of development: day 0, 4, 8, 16, and 22. All samples were cultured in re...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000095985 | MassIVE
TranscriptomicsTranscription profiling of human CaCo-2 cells following various iron treatments
We investigated transcriptional response of CaCo-2 cells to iron treatments, we studied hemin effect by adding hemin to DMEM-FBS medium and iron deficiency effects in using an iron free medium compared to the same supplemented with FAC (ferric ammonium citrate). Experiment Overall Design: Biologica...
ORGANISM(S): Homo sapiens 
2008-01-19 | E-GEOD-3573 | biostudies-arrayexpress
UnknownAntiviral effects of ferric ammonium citrate.
Not available
S-EPMC5871618 | biostudies-literature
TranscriptomicsIron excess limits HHIPL2 gene expression and decreases osteoblastic activity in human MG-63 cells
Our transcriptomic data shows that iron impact on human osteoblastic MG-63 cells by decreasing HHIPL-2 gene expression (2 fold ratio). This impact is corrected in presence of deferoxamine. Additional biological experiments in the manuscript suggest that the iron related modulation of HHIPL-2 gene ...
ORGANISM(S): Homo sapiens 
2012-09-01 | E-GEOD-30774 | biostudies-arrayexpress
TranscriptomicsEffects of Lipocalin 2 (Lcn2), iron, and the bacterial siderophore Enterobactin on A549 respiratory cell gene expression
Iron is essential for many cellular processes and is required by bacteria for replication. To acquire iron from the host, pathogenic Gram-negative bacteria secrete siderophores, including Enterobactin (Ent). However, Ent is bound by the host protein Lipocalin 2 (Lcn2), preventing bacterial reuptake ...
ORGANISM(S): Homo sapiens 
2014-07-03 | E-GEOD-54962 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Geobacter sulfurreducens grown in batch culture with either ferric citrate or graphite anodes as the electron acceptor
G. sulfurreducens (ATCC #51573) was obtained from the laboratory culture collection of Dr. Derek Lovley. Cells were grown under strict anaerobic conditions at 23 °C in batch culture. Both control and experimental populations were grown with 10mM acetate as the electron donor while Fe(III) as 55 mM f...
ORGANISM(S): Geobacter sulfurreducens 
2007-07-02 | E-TIGR-5001 | biostudies-arrayexpress
ProteomicsProteomic Profiling of iPSC-Derived Retinal Pigment Epithelium following Ferric Ammonium Citrate Treatment
iPSC-derived retinal pigment epithelium (iPSC-RPE) cells were cultured in vitro under standard conditions. The cells were then subjected to either a control treatment or treatment with 200 µM ferric ammonium citrate (FAC) for a period of 10 days to induce iron overload. Following the treatment perio...
ORGANISM(S): Homo Sapiens 
2026-01-11 | PXD072937 |
ProteomicsGlobal Proteomic Profiling in Chronic Iron-Exposed Fallopian Tube Secretory Epithelial Cells
We previously published (Oncogenesis, Rockfield et al., 2019) that chronic iron exposure (with ferric ammonium citrate, FAC) in immortalized fallopian tube secretory epithelial cells resulted in increased growth and migratory propensity. Our focused analyses identified a subset of oncogenic markers,...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018416 | Pride
Initiation events Ovarian cancer Proteomic profiling Fallopian tube secretory epithelial cells Ferric ammonium citrate 
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