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TranscriptomicsRNA-seq based transcriptome analysis of a highly virulent and multidrug resistant MRSA isolate for the understanding of virulence and resistance mechanisms
Staphylococcus aureus can infect a wide range of animals and pose as a serious threat to public health by transferring via animals or animal-derived food stuff. Even more importantly, multiple drug resistance development in the bacteria has resulted in therapeutic failure of a number of antibiotics....
ORGANISM(S): Staphylococcus aureus 
2016-03-02 | E-GEOD-78764 | biostudies-arrayexpress
no omics definedTranscription profiling of teicoplanin-susceptible strain of S.aureus and its teicoplanin-resistant derivative
Changes in transcriptome of S. aureus linked with acquisition of teicoplanin resistance and reduced autolysis. Comparison of RNA profiling of the teicoplanin-susceptible parental strain (MRGR3)with its teicoplanin-resistant derivative (14-4).
ORGANISM(S): Staphylococcus aureus 
2007-01-01 | E-MEXP-738 | biostudies-arrayexpress
TranscriptomicsPolyunsaturated dietary fats decrease mortality and bacterial load during septic S. aureus infection, and improve neutrophil function in mice
Severe infections and sepsis is an increasing clinical problem that cause prolonged morbidity and substantial mortality. At present, antibiotics are essentially the only pharmacological treatment for sepsis. The incidence of antibiotic resistance is increasing and it is therefore critical to find ne...
ORGANISM(S): Mus musculus 
2014-11-24 | E-GEOD-58358 | biostudies-arrayexpress
TranscriptomicsSarZ is a key regulator of biofilm formation and virulence in Staphylococcus epidermidis
Biofilm-associated infection by the leading nosocomial pathogen Staphylococcus epidermidis is a major problem for the public health system. Here we used an especially discriminatory, two-step screen to discover key biofilm factors. We identified the transcriptional regulator and SarA paralog SarZ as...
ORGANISM(S): Staphylococcus epidermidis 
2010-05-25 | E-GEOD-8523 | biostudies-arrayexpress
ProteomicsTumor matrix stiffness induces CCN1/CYR61 upregulation of N-Cadherin to promote cancer cell trans-endothelial migration and metastasis
Tumor progression is often accompanied with increased extracellular matrix stiffness, but how this affects endothelial cells (ECs) is largely unknown. We used mass spectrometry to analyse the proteomic changes of primary human ECs cultured on physiological or tumor stiffness and found that CCN1/CYR6...
ORGANISM(S): Homo sapiens (Human) 
2017-07-07 | PXD003316 | Pride
Stiffness  protome  silac  ccn1  matrigel  huvec  tumour  vasculature 
UnknownMeasuring facility readiness to provide childbirth care: a comparison of indices using data from a health facility survey in Ethiopia.
Not available
S-EPMC8493923 | biostudies-literature
TranscriptomicsTranscription profiling of Bos taurus immature oocytes and 8-cell embryos to assess the impact of the loss of sample representation caused by the use of global linear amplification (T7-IVT) during microarray hybridization sample preparation
Assessing the impact of the loss of sample representation caused by the use of global linear amplification (T7-IVT) during microarray hybridization sample preparation.
ORGANISM(S): Bos taurus 
2009-03-25 | E-MEXP-2099 | biostudies-arrayexpress
UnknownStaphylococcus aureus Strain USA300 Perturbs Acquisition of Lysosomal Enzymes and Requires Phagosomal Acidification for Survival inside Macrophages.
Not available
S-EPMC4694005 | biostudies-literature
TranscriptomicsComparative genomic hybridization of Bordetella bronchiseptica strains 253 and RB50 to investigate the cya adenylate cyclase toxin (ACT) operon
Bordetella bronchiseptica is a gram-negative respiratory pathogen that causes a diverse spectrum of respiratory disease in a wide-range of hosts. We sought to determine if strains of B. bronchiseptica differed in virulence using the mouse model of infection. Mean lethal doses (LD50) of different B...
ORGANISM(S): Bordetella bronchiseptica 
2007-10-01 | E-MEXP-1205 | biostudies-arrayexpress
TranscriptomicsIdentification of novel gene amplification events in breast cancer
To identify novel gene amplification events that may contribute to breast cancer progression, we examined copy number variation in 161 primary breast cancer samples using the Affymetrix 250K_Nsp and 250K_Sty microarrays or the Affymetrix SNP5.0 microarray. Affymetrix SNP arrays were performed accor...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-16619 | biostudies-arrayexpress
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