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TranscriptomicsBMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors
The transition from progenitor to differentiated cells is critical for successful organogenesis; subtle alterations in this process can lead to developmental disorders. The anterior heart field (AHF) encompasses a niche in which cardiac progenitors maintain their multipotent and undifferentiated nat...
ORGANISM(S): Gallus gallus 
2010-08-01 | E-GEOD-19698 | biostudies-arrayexpress
TranscriptomicsFGF-dependent regulation of VEGF signaling via transcriptional control of VEGF receptor 2 expression
Numerous studies have suggested a link between fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF) signaling pathways; however the nature of this link has not been established. To evaluate this relationship we investigated VEGF signaling in endothelial cells with disrupted F...
ORGANISM(S): Mus musculus 
2011-06-07 | E-GEOD-28483 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Xenopus embryos in which fibroblast growth factor (FGF) signalling was inhibited by two different dominant negative FGF receptors
Genes regulated by the fibroblast growth factor (FGF) signalling pathway were indentified in the early development of the amphibian Xenopus laevis by comparing gene expression in control embryos and embryos in which FGF signalling was inhibited by two different dominant negative FGF receptors.
ORGANISM(S): Xenopus laevis 
2009-03-01 | E-MEXP-2058 | biostudies-arrayexpress
TranscriptomicsFGF inhibition directs BMP4-mediated differentiation of Human Embryonic Stem Cells to syncytiotrophoblast
Bone morphogenetic protein (BMP) signaling is known to support differentiation of human embryonic stem cells (hESCs) into mesoderm and extraembryonic lineages, whereas other signaling pathways can largely influence this lineage specification. Here, we set out to reinvestigate the influence of ACTIVI...
ORGANISM(S): Homo sapiens 
2012-10-17 | E-GEOD-30125 | biostudies-arrayexpress
ProteomicsFGF signaling modulates lysosome biogenesis in chondrocytes via the Mannose Phosphate Receptor pathway
The mannose-6-phosphate (M6P) pathway is critical for lysosome biogenesis, facilitating the trafficking of hydrolases to lysosomes to ensure cellular degradative capacity [1], [2]. Fibroblast Growth Factor (FGF) signaling, a key regulator of skeletogenesis [3], has been linked to the autophagy-lysos...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-08-25 | PXD063029 | Pride
Lysosome Fgf Chordrocytes 
ProteomicsFGF signaling modulates lysosome biogenesis in chondrocytes via the Mannose Phosphate Receptor pathway
The mannose-6-phosphate (M6P) pathway is critical for lysosome biogenesis, facilitating the trafficking of hydrolases to lysosomes to ensure cellular degradative capacity [1], [2]. Fibroblast Growth Factor (FGF) signaling, a key regulator of skeletogenesis [3], has been linked to the autophagy-lysos...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-08-25 | PXD063031 | Pride
Chondrocytes Lysosome Fgf 
ProteomicsFGF signaling modulates lysosome biogenesis in chondrocytes via the Mannose Phosphate Receptor pathway
The mannose-6-phosphate (M6P) pathway is critical for lysosome biogenesis, facilitating the trafficking of hydrolases to lysosomes to ensure cellular degradative capacity [1], [2]. Fibroblast Growth Factor (FGF) signaling, a key regulator of skeletogenesis [3], has been linked to the autophagy-lysos...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-08-25 | PXD063036 | Pride
Chondrocytes Lysosome Fgf 
ProteomicsProfiling of Y1 cells treated with FGF-2 reveals parallels with oncogene-induced senescence
Paradoxically, oncogenes that drive cell cycle progression may also trigger pathways leading to senescence, thereby inhibiting the growth of tumorigenic cells. Along these lines, Y1 cells, which carry an amplification of Ras, become senescent after treatment with the mitogen FGF-2. To understand h...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-16 | PXD020688 | Pride
Fgf-2 Phosphorylation Cell cycle Senescence 
ProteomicsPhosphoproteomics of FGF signaling in Chrondrocytes
To understand the determinants of chondrocyte FGF inhibitory response we sought to identify the unique set of proteins whose phosphorylation status is changed upon FGF treatment. RCS (Rat ChondroSarcoma) (RCS) cells were used for our experiments as a well-accepted model of proliferative chondrocytes...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2016-10-20 | MSV000080259 | MassIVE
TranscriptomicsTranscription profiling of human fibroblasts stimulated with PDGF-BB or b-FGF
We analyzed gene expression in human fibroblasts stimulated by platelet-derived growth factor-BB (PDGF-BB) or basic fibroblast growth factor (bFGF) for 1h and 24h. The results of two independent experiments were merged. SAM analysis identified 116 relevant probe sets. Hierarchical clustering of thes...
ORGANISM(S): Homo sapiens 
2009-03-20 | E-GEOD-14256 | biostudies-arrayexpress
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