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ProteomicsProfiling of Y1 cells treated with FGF-2 reveals parallels with oncogene-induced senescence
Paradoxically, oncogenes that drive cell cycle progression may also trigger pathways leading to senescence, thereby inhibiting the growth of tumorigenic cells. Along these lines, Y1 cells, which carry an amplification of Ras, become senescent after treatment with the mitogen FGF-2. To understand h...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-16 | PXD020688 | Pride
Fgf-2 Phosphorylation Cell cycle Senescence 
TranscriptomicsTranscription profiling of neural stem cells treated with FGF-2, PDGF-AA or in the absence of growth factor (differentiation)
We compared the gene expression profiles of neural stem cells treated with FGF-2, PDGF-AA or in the absence of growth factor (differentiation). Cells grown in the presence of FGF-2 were used as a reference.
ORGANISM(S): Rattus norvegicus 
2006-03-15 | E-TABM-39 | biostudies-arrayexpress
ProteomicsImpact of FGF-2 and FGF-2 containing cell culture supernatants on the intracellular protein composition of ReNcell derived neuron
FGF-2 is an important protein involved in a vast number of molecular pathways and a number of cellular functions including glial cell differentiation and response to axon injury. This protein was found to be present significantly in supernatants of female derived murine oligodendrocyte progenitor ce...
ORGANISM(S): Homo sapiens (Human) 
2025-09-29 | PXD060285 | Pride
Human neural progenitor cell line Rencell vm Opc cell culture supernatant Fgf-2 Secretome lc-ms/ms 
TranscriptomicsFGF-dependent regulation of VEGF signaling via transcriptional control of VEGF receptor 2 expression
Numerous studies have suggested a link between fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF) signaling pathways; however the nature of this link has not been established. To evaluate this relationship we investigated VEGF signaling in endothelial cells with disrupted F...
ORGANISM(S): Mus musculus 
2011-06-07 | E-GEOD-28483 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse fibroblasts expressing different Fibroblast Growth Factor-2 forms
Fibroblast Growth Factor-2 (FGF-2) induces cell proliferation, cell migration, embryonic development, cell differentiation, angiogenesis and malignant transformation. The four forms of FGF-2 (Low Molecular Weight) and (High Molecular Weights) are alternative translation products, and have a differen...
ORGANISM(S): Mus musculus 
2006-11-11 | E-SMDB-3872 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human mesenchymal stromal cells cultured in PEG hydrogels with and without FGF-2
FGF-2 is commonly used in culture media when growing mechenchymal stromal cells. Here, we cultured human MSCs from 3 donors with and without 50 ng/ml FGF-2 (Prepotech, human recombinant) in 3D PEG hydrogels, and analysed transcriptome changes by RNA sequencing.
ORGANISM(S): Homo sapiens 
2020-06-02 | E-MTAB-8510 | biostudies-arrayexpress
GenomicsFGF-2 signaling dominates in TGF-β1/FGF-2–primed nasoseptal chondrocytes for cartilage tissue engineering
FGF-2 signaling dominates in TGF-β1/FGF-2–primed nasoseptal chondrocytes for cartilage tissue engineering
PRJNA1459423 | ENA
ProteomicsThe Fgf/Erf/NCoR1/2 repressive axis controls trophoblast cell fate
Here, we demonstrate that upon inhibition of the Fgf/Erk pathway in mouse trophoblast stem cells (TSCs), the Ets2 repressor factor (Erf) interacts with components of the Nuclear Receptor Corepressor Complex 1 and 2 (NCoR1 and NCoR2). Upon attenuation of Fgf signalling, unphosphorylated, nuclear Erf ...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-26 | PXD037892 | Pride
Trophoblast stem cells Erf Ncor2 Ncor1 
ProteomicsAn FGF-2 signaling pathway that is activated in aged skeletal muscle promotes intramuscular adipogenesis
Aged skeletal muscle is markedly affected by fatty muscle infiltration and strategies to reduce the occurrence of adipocytes within skeletal muscle, the intramuscular adipose tissue (IMAT), are urgently needed. Fibroblast growth factor-2 (FGF-2) is a critical growth factor for muscle tissue. Here, w...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-23 | PXD020575 | Pride
Lc-msms Imat Microrna Muscle 
GenomicsRole of FGF-2 induced non-coding RNA in cancer [II]
Role of FGF-2 induced non-coding RNA in cancer [II]
PRJNA786346 | ENA
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