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ProteomicsIdentification and functional characterization of NCoR1-interacting proteins associated with mitochondrial biogenesis
This study was designed to identify putative NCoR1-interacting proteins that might regulate the mitochondrial biogenesis process. To do that, MEF cells were transiently transfected with plasmid expressing either pcDNA-GFP-FLAG (control) or pCMX-NCoR1-FLAG and subjected to co-IP and identification of...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD040945 | Pride
Ncor1 Mitochondria Biogenesis Mass spectrometry Co-ip 
TranscriptomicsRNA-seq of Control and NCoR1 KD CD8α+ DCs at 0hr and 6hr of stimulation
RNA-seq was performed to understand the role of NCoR1 in CD8α+ DCs. MutuDC cell line was transduced with empty and Ncor1 shrna lentiviral particles and cells were prepared in unstimulated, 2hr and 6hr (IFNg, pIC and CpG+pIC+IFNg) stimulation condition.
ORGANISM(S): Mus musculus 
2022-09-20 | E-MTAB-10989 | biostudies-arrayexpress
GenomicsChIP-seq of NCoR1 in CD8α+ DCs at 6hr of stimulation
ChIP-seq of NCoR1 was performed to identify binding sites of NCoR1 in TLR dependent manner. MutuDC1940 cell line were treated with TLR3 ligand poly(I:C) and combined stimulation of TLR9 (CpG-B), TLR3, and IFNg for 6hr.
ORGANISM(S): Mus musculus 
2025-12-03 | E-MTAB-10991 | biostudies-arrayexpress
ProteomicsThe Fgf/Erf/NCoR1/2 repressive axis controls trophoblast cell fate
Here, we demonstrate that upon inhibition of the Fgf/Erk pathway in mouse trophoblast stem cells (TSCs), the Ets2 repressor factor (Erf) interacts with components of the Nuclear Receptor Corepressor Complex 1 and 2 (NCoR1 and NCoR2). Upon attenuation of Fgf signalling, unphosphorylated, nuclear Erf ...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-26 | PXD037892 | Pride
Trophoblast stem cells Erf Ncor2 Ncor1 
TranscriptomicsGene expression analysis of Ncor1 muscle-specific knockout and PGC-1alpha muscle-specific transgenic skeletal muscle
In the present study we have studied the mechanistic and functional aspects of NCoR1 function in mouse skeletal muscle. NCoR1 muscle-specific knockout mice exhibited an increased oxidative metabolism. Global gene expression analysis revealed a high overlap between the effects of NCoR1 deletion and p...
ORGANISM(S): Mus musculus 
2013-01-08 | E-GEOD-40439 | biostudies-arrayexpress
TranscriptomicsNuclear Receptor Co-repressor NCoR1 governs immune-tolerance in conventional dendritic cells by fine-tuning glycolysis and fatty acid oxidation
In this study, we focused on demonstrating the metabolic aspect of NCoR1 in the regulation of dendritic cells (DCs) functionality. We report that NCoR1 deficient tolerogenic DCs meet their anabolic requirements through enhanced glycolysis and OxPhos, supported by FAO-driven oxygen consumption. Furth...
ORGANISM(S): Mus musculus 
2024-01-01 | E-MTAB-12066 | biostudies-arrayexpress
GenomicsChIP-seq of H3K27ac in Control and NCoR1 KD CD8α+ DCs at 0hr, 2hr and 6hr of TLR stimulation
H3K27ac ChIP-seq was performed to identify active enhancers in different TLR activated control CD8α+ DCs as well as to understand the role of NCoR1 in regulating TLR specific enhacner activity using H3K27ac ChIP-seq performed in NCoR1 KD DCs. MutuDC1940 cell line were treated with TLR3 ligand poly I...
ORGANISM(S): Mus musculus 
2025-12-03 | E-MTAB-10992 | biostudies-arrayexpress
GenomicsNCoR1 limits angiogenic capacity by altering Notch signaling
NCoR1 limits angiogenic capacity by altering Notch signaling
PRJNA996109 | ENA
GenomicsNCoR1 limits angiogenic capacity by altering Notch signaling [RNA]
NCoR1 limits angiogenic capacity by altering Notch signaling [RNA]
PRJNA996110 | ENA
GenomicsNCOR1 sustains CRC growth and protects from cellular senescence
NCOR1 sustains CRC growth and protects from cellular senescence
PRJNA728731 | ENA
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