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TranscriptomicsExpression data from lung of mice bearing mutations of FGFR3 and FGFR4
Gene expression profiling of newborn lung tissue revealed few changes in compound FGFR3/FGFR4 deficient mice, consistent with their normal lung morphology at birth, suggesting the sequence of events leading to the phenotype initiates after birth in this model. Profiling of 4 week-old lung tissues re...
ORGANISM(S): Mus musculus 
2010-04-12 | E-GEOD-15452 | biostudies-arrayexpress
ProteomicsStrategies to inhibit FGFR4 V550L-driven rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is a paediatric cancer driven either by a fusion protein (e.g. PAX3-FOXO1) or by mutations in key signalling molecules (e.g. RAS or FGFR4). Despite the latter giving potential for precision medicine approaches in RMS, there are no such treatments implemented in the clinic yet....
ORGANISM(S): Homo sapiens (Human) 
2022-10-19 | PXD029719 | Pride
Proteomics Rhabdomyosarcoma Fgfr4 V550l 
GenomicsTargeting FGFR4 Abrogates HNF1A-driven Metastasis in Pancreatic Ductal Adenocarcinoma
Targeting FGFR4 Abrogates HNF1A-driven Metastasis in Pancreatic Ductal Adenocarcinoma
PRJNA1255480 | ENA
TranscriptomicsExpression data from fibroblast growth factor receptor 4 (FGFR4) knock down ovarian cancer cell lines
Advanced ovarian cancer is the most lethal gynecologic malignancy in the United States. Currently patients are treated by surgical cytoreductive surgery with the aim of reducing tumor burden to microscopic disease followed by adjuvant combined treatment with a platinum and taxane containing chemothe...
ORGANISM(S): Homo sapiens 
2013-12-03 | E-GEOD-34828 | biostudies-arrayexpress
GenomicsMolecular mechanisms of Guadecitabine induced FGFR4 down regulation in alveolar rhabdomyosarcomas
Molecular mechanisms of Guadecitabine induced FGFR4 down regulation in alveolar rhabdomyosarcomas
PRJNA632891 | ENA
TranscriptomicsGene expression profiles of PNT1a prostate cells expressing FGFR-4 Arg388 or Gly388.
We have shown that in PNT1a cells expressing exogenous FGFR4 Arg388 or Gly388 under the control of the EF1 promoter almost all FGFR signaling can be attributed to the transfected receptor, and the two FGFR-4 isoforms are expressed at equivalent levels in the two cell lines. Furthermore, we have show...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-20906 | biostudies-arrayexpress
GenomicsBCL-XL inhibition induces an FGFR4 mediated rescue response in colorectal cancer
BCL-XL inhibition induces an FGFR4 mediated rescue response in colorectal cancer
PRJNA669160 | ENA
TranscriptomicsTargeting FGFR4 Abrogates HNF1A-driven Metastasis in Pancreatic Ductal Adenocarcinoma
Background: We previously identified an oncogenic role for the transcription factor HNF1A in pancreatic ductal adenocarcinoma (PDAC). However, the role of HNF1A in the metastatic progression of PDAC remains unknown and targeting modalities for HNF1A-dependent phenotypes have yet to be identified. Me...
ORGANISM(S): Homo sapiens 
2025-07-29 | GSE295616 | GEO
GenomicsFGFR4 is a key regulator of tumor subtype differentiation in luminal breast cancer and metastatic disease [set 1]
FGFR4 is a key regulator of tumor subtype differentiation in luminal breast cancer and metastatic disease [set 1]
PRJNA520843 | ENA
GenomicsFGFR4 is a regulator of tumor subtype differentiation in luminal breast cancer and metastatic disease
FGFR4 is a regulator of tumor subtype differentiation in luminal breast cancer and metastatic disease
PRJNA606764 | ENA
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