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TranscriptomicsGENOMIC ANALYSIS OF FIBROLAMELLAR HEPATOCELLULAR CARCINOMA REVEALS A UNIQUE MOLECULAR PROFILE
Fibrolamellar hepatocellular carcinoma (FLC) is a rare primary hepatic cancer usually developed in non-cirrhotic livers of children and young adults with unknown etiology. Treatment is limited to surgical intervention. To date, molecular pathogenesis of FLC has been poorly characterized. A cohort of...
ORGANISM(S): Homo sapiens 
2015-02-12 | E-GEOD-59443 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Pure Fibrolamellar Hepatocellular carcinoma
A Cartes d'Identite des Tumeurs (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net) | Affymetrix HG-U133 Plus 2.0 : 5 mixed fibrolamellar carcinoma (m-FLC), 17 pure fibrolamellar carcinoma (p-FLC), 7 hepatocelluar carcinoma arising in non-cirrhotic liver (nc...
ORGANISM(S): Homo sapiens 
2014-08-15 | E-MTAB-1503 | biostudies-arrayexpress
TranscriptomicsGenomic analysis of Fibrolammellar Hepatocellular Carcinoma reveals an unique molecular profile [Test set]
Background & Aims: Fibrolamellar hepatocellular carcinoma (FLC) is a rare primary hepatic cancer usually developed in non-cirrhotic livers of children and young adults with unknown etiology. Treatment is limited to surgical intervention. To date, molecular pathogenesis of FLC has been poorly char...
ORGANISM(S): Homo sapiens 
2015-02-12 | E-GEOD-57726 | biostudies-arrayexpress
TranscriptomicsGenomic analysis of Fibrolammellar Hepatocellular Carcinoma reveals an unique molecular profile [Training set]
Background & Aims: Fibrolamellar hepatocellular carcinoma (FLC) is a rare primary hepatic cancer usually developed in non-cirrhotic livers of children and young adults with unknown etiology. Treatment is limited to surgical intervention. To date, molecular pathogenesis of FLC has been poorly char...
ORGANISM(S): Homo sapiens 
2015-02-12 | E-GEOD-57725 | biostudies-arrayexpress
ProteomicsDisruption of proteome by an oncogenic fusion kinase alters metabolism in fibrolamellar hepatocellular carcinoma
Fibrolamellar hepatocellular carcinoma (FLC) is a usually lethal primary liver cancer driven by a somatic dysregulation of protein kinase A. We show that the proteome of FLC tumors is distinct from that of adjacent nontransformed tissue. These changes can account for some of the cell biological and ...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD046905 | Pride
Proteomics Fibrolamellar hepatocellular carcinoma Flc 
ProteomicsProteomic profiling in fibrolamellar carcinoma patient tumor tissue
Fibrolamellar carcinoma (FLC) is a rare, early-onset liver cancer. The five-year survival rate is low, and there is a critical need for new therapeutics. The primary driver in FLC is the fusion oncoprotein, DNAJ-PKAc, which remains challenging to target therapeutically. It is critical, therefore,...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051527 | Pride
Primary Cancer Flc Non-malignant Human Liver Fibrolamellar carcinoma Frozen tissue Metastatic 
UnknownRoad map for fibrolamellar carcinoma: progress and goals of a diversified approach.
Not available
S-EPMC6362920 | biostudies-literature
GenomicsChromatin run-on and RNA sequencing of fibrolamellar carcinoma
Fibrolamellar carcinoma (FLC) is a rare, therapeutically intractable liver cancer that disproportionately affects youth. Here we used chromatin run-on sequencing to characterize the enhancer landscape in FLC and RNA sequencing to identify dysregulated genes in FLC.
EGAS00001004169 | EGA
ProteomicsThe oncogenic fusion protein DNAJB1-PRKACA can be specifically targeted by peptide-based immunotherapy in fibrolamellar hepatocellular carcinoma
The DNAJB1-PRKACA fusion transcript is the oncogenic driver in fibrolamellar hepatocellular carcinoma, a lethal disease lacking specific therapies. This study reports on the identification, characterization, and immunotherapeutic application of HLA-presented neoantigens specific for the DNAJB1-PRKAC...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD029882 | Pride
Cancer Hla ligands Mass spectrometry Fibrolamellar hepatocellular carcinoma Immunopeptidomics Fl-hcc 
GenomicThe Genome and Transcriptome of Fibrolamellar Hepatocellular Carcinoma

Fibrolamellar hepatocellular carcinoma (FL-HCC) is a rare liver tumor primarily affecting adolescents and young adults. Little is known of the molecular pathogenesis. To characterize the disease we performed RNA sequencing and whole genome sequencing on FL-HCC tumors and adjacent normal tissue. T...

phs000709 | dbGaP
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