Sort   by:  
 Page size 
MetabolomicsPhototrophic biofilm assembly in microbial-mat-derived unicyanobacterial consortia: model systems for the study of autotroph-heterotroph interactions
Microbial autotroph-heterotroph interactions influence biogeochemical cycles on a global scale, but the diversity and complexity of natural systems and their intractability to in situ manipulation make it challenging to elucidate the principles governing these interactions. The study of assembling p...
2014-06-24 | MTBLS75 | MetaboLights
MetabolomicsTFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis
The mechanisms underlying cancer metastasis remain poorly understood. Here, we report that TFAM deficiency rapidly and stably induced spontaneous lung metastasis in mice with liver cancer. Interestingly, unexpected polymerization of nuclear actin was observed in TFAM-knockdown HCC cells when cytoske...
2022-06-23 | MTBLS4307 | MetaboLights
ProteomicsIdentification of CTPS1 Filament Interacting Proteins
CTP synthase (CTPS) catalyzes the formation of CTP in de novo pyrimidine biosynthesis pathway. Compartmentalization of CTPS into filamentous structure is evolutionarily conserved from E.coli, yeast, Drosophila, mice to humans. Recently, we have demonstrated that histidine-mediated protein methylatio...
ORGANISM(S): Homo sapiens (Human) 
2020-03-24 | PXD010921 | Pride
Snap29 Apex2 Ctps Cytokeratin 
TranscriptomicsMYBPH, a novel transcriptional target of NKX2-1/TTF-1, inhibits ROCK1 and actomyosin assembly, and reduces cell motility and tumor metastasis
Cell migration driven by actomyosin filament assembly is a critical step in tumour invasion and metastasis. Herein, we report identification of myosin binding protein H (MYBPH) as a transcriptional target of NKX2-1 (also known as TTF-1 and TITF1), a lineage-survival oncogene in lung adenocarcinoma. ...
ORGANISM(S): Homo sapiens 
2011-12-22 | E-GEOD-26721 | biostudies-arrayexpress
ProteomicsStructural basis for assembly of lamin at the molecular level
Nuclear structure and function are governed by lamins, which are intermediate filaments mostly consisting of alpha-helices. Different lamin assembly models have been proposed based on low resolution or fragmented structures. However, their assembly mechanisms at the molecular level are poorly unders...
ORGANISM(S): Homo sapiens (Human) 
2019-08-26 | PXD013144 | Pride
Chemical crosslinking Nuclear lamin protein X-ray crystallography Gel-based lc-msms Filament assembly structure 
UnknownThe structure and assembly mechanism of a novel three-stranded tubulin filament that centers phage DNA.
Not available
S-EPMC3999902 | biostudies-literature
UnknownDynactin 3D structure: implications for assembly and dynein binding.
Not available
S-EPMC4216434 | biostudies-literature
ProteomicsIdentification of CTPS1 Filament Interacting Proteins_2019 dataset
CTP synthase (CTPS) catalyzes the formation of CTP in de novo pyrimidine biosynthesis pathway. Compartmentalization of CTPS into filamentous structure is evolutionarily conserved from E.coli, yeast, Drosophila, mice to humans. Previously, we demonstrated that histidine (His) mediated methylation pro...
ORGANISM(S): Homo sapiens (Human) 
2020-03-24 | PXD015507 | Pride
Apex2 Tmt6 labeling Ctps1 Lc-ms/ms 
UnknownSeptin structure and filament assembly.
Not available
S-EPMC5662055 | biostudies-literature
TranscriptomicsDeleterious assembly of the lamin A/C mutant p.S143P causes ER stress in familial dilated cardiomyopathy
Mutation of the LMNA gene, encoding nuclear lamin A and lamin C (hereafter lamin A/C), is a common cause of familial dilated cardiomyopathy (DCM). Among Finnish DCM patients, the founder mutation c.427T>C (p.S143P) is the most frequently reported genetic variant. Here, we show that p.S143P lamin A/C...
ORGANISM(S): Homo sapiens 
2016-06-10 | E-GEOD-82290 | biostudies-arrayexpress
Sort   by:  
 Page size