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ProteomicsProteome alterations in Filamin A deficient granulosa cell tumor-derived KGN cells.
The goal of the study was to evaluate consequences of Filamin A deficiency in granulosa cell tumor-derived KGN cells. Therefore, proteomes of WT and Filamin A deficient KGN cells were quantitatively compared using LC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2026-05-22 | PXD064136 | Pride
Filamin a Kgn-cells Ovarian cancer Granulosa cells 
ProteomicsPhosphoproteomic analysis of neoadjuvant breast cancer reveals a subset of patients with increased sensitivity to paclitaxel driven by CDK4 and Filamin A.
Precision oncology research is challenging outside contexts of oncogenic addiction and/or targeted therapies. We previously showed that phosphoproteomics is a powerful approach to reveal patient subsets of interest characterized by the activity of a few kinases where the underlying genomics is compl...
ORGANISM(S): Homo sapiens (Human) 
2022-11-08 | PXD034355 | Pride
Breast cancer Filamin a Phosphoproteomics Cdk4 Paclitaxel 
TranscriptomicsA Chondrogenic Molecule that Repairs Cartilage by Transcriptional Regulation of CBF-beta
Osteoarthritis (OA) is a degenerative joint disease that involves destruction of articular cartilage and eventually leads to disability. Mesenchymal stem cells (MSCs) reside in healthy and diseased cartilage, and through their chondrogenic potential may provide a strategy for cartilage repair. To th...
ORGANISM(S): Homo sapiens 
2012-05-01 | E-GEOD-35546 | biostudies-arrayexpress
GenomicsA miR-200b-Filamin A axis drives epicardial contribution to cardiogenesis
A miR-200b-Filamin A axis drives epicardial contribution to cardiogenesis
PRJNA1368821 | ENA
ProteomicsFilamin C domain 18-21 in vitro kinase assay
In vitro kinase assay with human filamin C domain 18-21 recombinantly expressed in E.coli, purified by Ni2+-NTA beads and incubated with PKC alpha, Akt or a combination of both to identify kinase specific phosphorylation sites.
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2020-05-25 | PXD008893 | Pride
Filamin c Akt In vitro kinase assay Pkb Pkcalpha 
TranscriptomicsThe Refilin/Filamin complex regulates filipodia dynamics in oligodendrocyte progenitor cells.
Actin assembly and dynamics control the shape, motility and functions of diverse cell types. Programme for controlling theses dynamics is hard-coded into actin binding proteins and regulatory proteins. Refilins (RefilinA and RefilinB) are short lived regulatory proteins that interact with the actin-...
ORGANISM(S): Rattus norvegicus 
2013-05-01 | E-GEOD-37600 | biostudies-arrayexpress
GenomicsGenome-Wide Analyses Identify Filamin-A (FLNA) as a Novel Downstream Target for Insulin and IGF1 Action.
Genome-Wide Analyses Identify Filamin-A (FLNA) as a Novel Downstream Target for Insulin and IGF1 Action.
PRJNA429450 | ENA
GenomicsEdited Filamin A in myeloid cells reduces intestinal inflammation and protects from colitis [scRNA-Seq]
Edited Filamin A in myeloid cells reduces intestinal inflammation and protects from colitis [scRNA-Seq]
PRJNA1257419 | ENA
GenomicsEdited Filamin A in myeloid cells reduces intestinal inflammation and protects from colitis [RNA-Seq]
Edited Filamin A in myeloid cells reduces intestinal inflammation and protects from colitis [RNA-Seq]
PRJNA1257421 | ENA
GenomicsEdited Filamin A in myeloid cells reduces intestinal inflammation and protects from colitis
Edited Filamin A in myeloid cells reduces intestinal inflammation and protects from colitis
PRJNA1256771 | ENA
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