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TranscriptomicsProfiling of gender-regulated gene transcripts in the filarial nematode Brugia malayi by oligonucleotide array analysis
Microarray technology permits high throughput comparisons of gene expression in different parasite stages or sexes. We now report the first use of this technology for analysis of gene expression in filarial worms. The slide array (comprised of 65 mer oligos representing 3569 EST clusters) was spotte...
ORGANISM(S): Brugia malayi 
2010-06-10 | E-GEOD-2038 | biostudies-arrayexpress
TranscriptomicsCirculating Dirofilaria immitis microRNAs in dog plasma
We report the presence of circulating miRNAs released by the filarial nematode Dirofilaria immitis into the host (Canis familiaris) bloodstream. MiRNA deep-sequencing combined with bioinformatics revealed over 200 mature miRNA sequences of potential nematode origin in Dirofilaria immitis-infected do...
ORGANISM(S): Canis lupus familiaris 
2014-10-03 | E-GEOD-60170 | biostudies-arrayexpress
TranscriptomicsDual RNA-seq of parasite and host reveals gene expression dynamics during filarial worm-mosquito interactions
Parasite biology, by its very nature, cannot be understood without integrating it with that of the host, nor can the host response be adequately explained without considering the activity of the parasite. However, due to experimental limitations, molecular studies of parasite-host systems have been ...
ORGANISM(S): Aedes aegypti 
2014-04-15 | E-GEOD-53664 | biostudies-arrayexpress
ProteomicsComparative analysis of the secretome from a model filarial nematode (Litomosoides sigmodontis) reveals maximal diversity in gravid female parasites
Filarial nematodes (superfamily Filarioidea) are responsible for an annual global health burden of approximately 6.3 million disability-adjusted life-years, which represents the greatest single component of morbidity attributable to helminths affecting humans. No vaccine exists for the major filaria...
ORGANISM(S): Litomosoides sigmodontis (Filarial nematode worm) 
2014-07-22 | PXD000756 | Pride
Filarial nematode Excretory-secretory products Lc-ms/ms Litomosoides sigmodontis 
UnknownDetection of circulating parasite-derived microRNAs in filarial infections.
Not available
S-EPMC4102413 | biostudies-literature
TranscriptomicsTranscription profiling of of the human filarial nematode Brugia malayi across multiple life-cycle stages
High-throughput sequencing to profile the transcriptome of the human filarial nematode Brugia malayi, the causative agent of lymphatic filariasis, across multiple life-cycle stages.
ORGANISM(S): Brugia malayi 
2011-10-18 | E-MTAB-811 | biostudies-arrayexpress
ProteomicsCharacterisation of a novel glycosylated glutathione transferase of Onchocerca ochengi, closest relative of the human river blindness parasite
Filarial nematodes possess glutathione transferases (GSTs), ubiquitous enzymes with potential to detoxify xenobiotic and endogenous substrates, and modulate the host immune system, which may aid worm infection establishment, maintenance and survival in the host. Here we have identified and character...
ORGANISM(S): Onchocerca ochengi (Filarial nematode worm) 
2020-05-26 | PXD013440 | Pride
Glycosylation Onchocerca Prostaglandin synthase Detoxification Glycans Immune modulation Gsts 
ProteomicsN-glycosite mapping in Brugia malayi female worms, male worms, and microfilariae
N-linked glycosylation is a critical post translational modification of eukaryotic proteins. N-linked glycans are present on surface and secreted filarial proteins that play a role in host parasite interactions. Examples of glycosylated Brugia malayi proteins have been previously identified but ther...
ORGANISM(S): Brugia malayi 
2023-04-23 | PXD039002 | Pride
Lc-msms N-glyco fasp Filarial parasite 
UnknownGenomics of Loa loa, a Wolbachia-free filarial parasite of humans.
Not available
S-EPMC4238225 | biostudies-literature
UnknownAbsence of Wolbachia endobacteria in Chandlerella quiscali, an avian filarial parasite.
Not available
S-EPMC5000782 | biostudies-literature
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