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ProteomicsPathology-driven epithelial sulfide loss reprograms the redox proteome and triggers Barrett’s esophagus
Background & AimsBarrett’s esophagus (BE), a metaplastic transformation driven by gastroesophageal reflux disease (GERD), induces oxidative stress but the underlying redox mechanisms remain poorly understood. Protein persulfidation (PSSH), a redox-sensitive, reversible, and antioxidative post-transl...
ORGANISM(S): Homo sapiens (Human) 
2026-06-02 | PXD047338 | Pride
Persulfidation  hydrogen sulfide  barrett’s esophagus  gastroesophageal reflux disease (gerd)  prostaglandin e2/interleukin 1/mtor cross-talk 
ProteomicsNeurobehavioral dysfunction in a mouse model of Down syndrome: upregulation of cystathionine β-synthase, H2S overproduction, altered protein persulfidation, synaptic dysfunction, endoplasmic reticulum stress, and autophagy
Down syndrome (DS) is a genetic condition where the person is born with an extra chromosome 21. DS is associated with accelerated aging; people with DS are prone to age-related neurological conditions including an early-onset Alzheimer’s disease. Using the Dp(17)3Yey/ + mice, which overexpresses a p...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-30 | PXD048079 | Pride
Hydrogen sulfide  bioenergetics  gasotransmitters  proliferation  mitochondria 
ProteomicsMetabolic dysfunction-associated steatohepatitis reduces hepatic H2S- producing enzymes altering persulfidome composition
Metabolic dysfunction–associated steatohepatitis (MASH) is a progressive disease driven byobesity-related hepatic inflammation and oxidative stress. Recently, cysteine persulfidation (PSSH), a protective post-translational modification by hydrogen sulfide (H2S), was established to play a role in red...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-15 | PXD066952 | Pride
Persulfidome Obesity Mash 
ProteomicsProtein tyrosine phosphatase receptor kappa regulates glycolysis, de novo lipogenesis and promotes hepatocyte metabolic reprogramming in obesity.
Fat accumulation, de novo lipogenesis, and glycolysis are key contributors to hepatocyte reprogramming and the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD). The molecular mechanisms affected by steatosis and inflammation in the obese states remain unknown. Here we...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-21 | PXD046506 | Pride
Masld Obesity Phosphoproteomic Liver Ptprk 
ProteomicsEndogenously produced cyanide supports bioenergetics and exerts cytoprotective effects in mammals_HepG2 cells treated with 10mM Glycine, Glycine/Serine free medium or untreated
Small, gaseous molecules, known as gasotransmitters (NO, CO, H2S), are produced endogenously in mammalian cells and serve important biological roles. Cyanide (CN) is 35 known as an endogenous mediator in plants and bacteria, while in mammals it has been mainly viewed as a toxin. Here we show that lo...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD046184 | Pride
Cyanilation Cysteine modification 
ProteomicsEndogenously produced cyanide supports bioenergetics and exerts cytoprotective effects in mammals_Mice-liver
Small, gaseous molecules, known as gasotransmitters (NO, CO, H2S), are produced endogenously in mammalian cells and serve important biological roles. Cyanide (CN) is 35 known as an endogenous mediator in plants and bacteria, while in mammals it has been mainly viewed as a toxin. Here we show that lo...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD046065 | Pride
Cyanilation Cysteine modification 
ProteomicsEndogenously produced cyanide supports bioenergetics and exerts cytoprotective effects in mammals_HepG2 cells treated with cyanide releasers
Small, gaseous molecules, known as gasotransmitters (NO, CO, H2S), are produced endogenously in mammalian cells and serve important biological roles. Cyanide (CN) is 35 known as an endogenous mediator in plants and bacteria, while in mammals it has been mainly viewed as a toxin. Here we show that lo...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD046323 | Pride
Cyanilation Cysteine modification 
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