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ProteomicsThe Q Exactive HF, a Benchtop Mass Spectrometer with a Pre-filter, High Performance Quadrupole and an Ultra-High Field Orbitrap Analyzer
The quadrupole Orbitrap mass spectrometer (Q Exactive) has made a powerful proteomics instrument available in a benchtop format. It significantly boosted analyzable proteins per hour and has now evolved into a proteomics analysis workhorse for many laboratories. Here we describe the Q Exactive Plus ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080865 | MassIVE
ProteomicsThe Q Exactive HF, a Benchtop Mass Spectrometer with a Pre-filter, High Performance Quadrupole and an Ultra-High Field Orbitrap Analyzer
The quadrupole Orbitrap mass spectrometer (Q Exactive) has made a powerful proteomics instrument available in a benchtop format. It significantly boosted analyzable proteins per hour and has now evolved into a proteomics analysis workhorse for many laboratories. Here we describe the Q Exactive Plus ...
ORGANISM(S): Homo sapiens (Human) 
2014-11-10 | PXD001203 | Pride
Segmented quadrupole Q exactive hf Orbitrap ultra-high field Q exactive plus Quadrupole pre-filter Shotgun proteomics 
ProteomicsProteomics characterisation of the L929 cell supernatant and its role in BMDM differentiation
Bone marrow-derived macrophages (BMDMs) are a key model system for studying macrophage biology in vitro. Commonly used methods to differentiate macrophages from bone marrow are treatment with either recombinant M-CSF or the supernatant of L929 cells, which secrete M-CSF. However, little is known abo...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-13 | PXD021026 | Pride
L929 Proteomics Differentiation M-csf Bone marrow-derived macrophages Secretome 
ProteomicsSecretome Analysis of Mycobacterial-infected Bovine Macrophages
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, a chronic granulomatous disease. Mtb is mostly restricted to humans and seldom causes disease in animals. M. bovis (Mbv) on the other hand causes tuberculosis in cows (bovine tuberculosis) and several wild animals. Each of thes...
ORGANISM(S): Bos taurus (Bovine) 
2021-03-11 | PXD017949 | Pride
Mycobacterium tuberculosis Bovine macrophages Mycobacterium bovis Host-pathogen interactions Tropism 
ProteomicsChemBioID - An integrated chemical biology workflow for the investigation of proximity-induced pharmacology of BIRC2 by the compounds AZD5582 and GDC0152
Modulation of protein-protein interactions with small molecules represents an emerging area of interest in drug discovery, enabling new therapeutic paradigms unprecedented with other drug classes such as catalytic enzyme inhibitors. Immunomodulatory drugs are a prime example for proximity-induced ph...
ORGANISM(S): Homo sapiens (Human) 
2025-04-30 | PXD056535 | Pride
Hek293 Bioid Lc-ms/ms 
ProteomicsChemBioID - An integrated chemical biology workflow for the investigation of proximity-induced pharmacology of BIRC3 by the compounds AZD5582 and GDC0152
Modulation of protein-protein interactions with small molecules represents an emerging area of interest in drug discovery, enabling new therapeutic paradigms unprecedented with other drug classes such as catalytic enzyme inhibitors. Immunomodulatory drugs are a prime example for proximity-induced ph...
ORGANISM(S): Homo sapiens (Human) 
2025-04-30 | PXD056541 | Pride
Hek293 Bioid Lc-ms/ms 
ProteomicsChemBioID - An integrated chemical biology workflow for the investigation of proximity-induced pharmacology by the compound NVS-BPTF-A-2
Modulation of protein-protein interactions with small molecules represents an emerging area of interest in drug discovery, enabling new therapeutic paradigms unprecedented with other drug classes such as catalytic enzyme inhibitors. Immunomodulatory drugs are a prime example for proximity-induced ph...
ORGANISM(S): Homo sapiens (Human) 
2025-04-30 | PXD056314 | Pride
Hek293 Bioid Lc-ms/ms 
ProteomicsChemBioID - An integrated chemical biology workflow for the investigation of proximity-induced pharmacology by the compound QL-BPTF-6
Modulation of protein-protein interactions with small molecules represents an emerging area of interest in drug discovery, enabling new therapeutic paradigms unprecedented with other drug classes such as catalytic enzyme inhibitors. Immunomodulatory drugs are a prime example for proximity-induced ph...
ORGANISM(S): Homo sapiens (Human) 
2025-04-30 | PXD056421 | Pride
Hek293 Bioid Lc-ms/ms 
ProteomicsChemBioID - An integrated chemical biology workflow for the investigation of proximity-induced pharmacology of CSNK by the compound lenalidomide
Modulation of protein-protein interactions with small molecules represents an emerging area of interest in drug discovery, enabling new therapeutic paradigms unprecedented with other drug classes such as catalytic enzyme inhibitors. Immunomodulatory drugs are a prime example for proximity-induced ph...
ORGANISM(S): Homo sapiens (Human) 
2025-04-30 | PXD056551 | Pride
Hek293 Bioid Lc-ms/ms 
MetabolomicsMetabolic Profiling of Volatile Organic Compounds (VOCs) Emitted by the Pathogens Francisella tularensis and Bacillus anthracis in Liquid Culture
We conducted comprehensive (untargeted) metabolic profiling of volatile organic compounds (VOCs) emitted in culture by bacterial taxa Francisella tularensis (F. tularensis) subspecies novicida and Bacillus anthracis (B. anthracis) Sterne, surrogates for potential bacterial bioterrorism agents, as we...
2020-08-20 | MTBLS1737 | MetaboLights
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