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MetabolomicsBrain corticogenesis promotes SARS-CoV-2 neuro-glial tropism through lipid-dependent viral replication
While extensive research has examined the neuroinvasiveness of SARS-CoV-2, its relationship with brain maturation remains unclear. Using a multi-omics approach, we established cerebral organoids (CBOs) at day 60 (EB60) and day 120 (EB120) to model immature and mature developmental stages. We found t...
2026-06-18 | MTBLS14790 | MetaboLights
ProteomicsTranscriptomic and proteomic landscape of SARS-CoV-2 liver tropism
Extrapulmonary manifestations of COVID-19 have gained attention, not only due to their links to clinical outcomes, but also due to their potential long-term sequelae1. Recent evidence has shown multi-organ tropism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including heart, kidn...
ORGANISM(S): Homo sapiens (Human) 
2022-04-02 | PXD022789 | Pride
Sars-cov-2 Liver tropism Hepatic 
ProteomicsMultiresolution imaging using bioluminescence resonance energy transfer identifies distinct biodistribution profiles of extracellular vesicles and exomeres with redirected tropism
Extracellular particles (EPs) including extracellular vesicles and exomeres play a significant role in diseases and therapeutic applications. However, the spatiotemporal dynamics of EPs in vivo remains to be elucidated with a suitable method. In this study, we developed a bioluminescence resonance e...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD020446 | Pride
Extracellular vesicles Hepatocellular carcinoma Microvesicles Exosomes Biodistribution Redirected tropism 
TranscriptomicsHost cell tropism of Propionibacterium acnes: infection scenarios differ on skin and prostate epithelia
Proprionibacterium acnes is a Gram positive bacterium found ubiquitously on human skin, where it is typically considered to assume a commensal relationship with its host. However, it is also closely associated with the skin condition acne vulgaris. More controversially, it has a postulated involveme...
ORGANISM(S): Homo sapiens 
2012-11-21 | E-GEOD-33731 | biostudies-arrayexpress
ProteomicsDirect Evolution of Adeno-Associated Virus 5 Capsid Enables Specific Liver Tropism
Gene therapy has been thriving in recent years, as featured by general triumphs in several clinical trials to treat hemophilia. It highlights the significance of AAV mediated gene delivery to liver. AAV5 is a unique serotype with low neutralizing antibody prevalence. In this study, we generated an A...
ORGANISM(S): Adeno-associated Virus - 5 
2022-04-01 | PXD032891 |
GenomicsStromal lipid species dictate melanoma metastasis and tropism [A375_RNA_seq]
Stromal lipid species dictate melanoma metastasis and tropism [A375_RNA_seq]
PRJNA1240335 | ENA
GenomicsStromal lipid species dictate melanoma metastasis and tropism [MeWo_RNA_seq]
Stromal lipid species dictate melanoma metastasis and tropism [MeWo_RNA_seq]
PRJNA1240334 | ENA
GenomicsStromal lipid species dictate melanoma metastasis and tropism [MFP_RNA_seq]
Stromal lipid species dictate melanoma metastasis and tropism [MFP_RNA_seq]
PRJNA1240333 | ENA
GenomicsTissue Tropism in Chlamydia pneumoniae Infection
Genomic Factors Related to Tissue Tropism in Chlamydia pneumoniae Infection
PRJEB8246 | ENA
GenomicsTropism for tuft cells determines norovirus pathogenesis
Intestinal tuft cells are the physiologic target cell of murine norovirus and this tropism determines transkingdom interactions.
PRJEB23132 | ENA
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