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TranscriptomicsEngineering Material Properties of Transcription Factor Condensates to Control Gene Expression in HEK-293T Cells
Phase separation of biomolecules into condensates is a key mechanism in the spatiotemporal organization of biochemical processes in cells. We systematically engineered light-inducible transcription factor condensates with different material properties and analyzed their influence on transcription ac...
ORGANISM(S): Homo sapiens 
2024-04-01 | E-MTAB-13905 | biostudies-arrayexpress
ProteomicsAdverse Effects of Bisphenol A and its substitute compounds on human SGBS preadipocytes
Bisphenol A (BPA), which is used in a variety of consumer-related plastic products, was reported to cause metabolic disruption. Substitute compounds are increasingly emerging, but are not sufficiently investigated. In this study, we aimed to investigate the mode of action of BPA and four of its subs...
ORGANISM(S): Homo sapiens (Human) 
2021-08-05 | PXD023227 | Pride
Bpa Adipocytes Sgbs Human Bisphenol a 
UnknownDevelopment and Validation of a Total Body Photo-Numeric Freckling Density Scale.
Not available
S-EPMC11439887 | biostudies-literature
MetabolomicsMapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum
Falciparum malaria is clinically heterogeneous and the relative contribution of parasite and host in shaping disease severity remains unclear. We explored the interaction between inflammation and parasite variant surface antigen (VSA) expression, asking whether this relationship underpins the variat...
2020-12-02 | MTBLS1188 | MetaboLights
ProteomicsMolecular solution to the paradox of ancient brain preservation
Brains are among the first organs to decompose after death, yet also some of the most commonly preserved soft tissues in the archaeological and fossil records. This paradox between rapid early decay and long-term survival has been known for at least four centuries, but has yet to be explained. Here ...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-01 | PXD074190 | Pride
ProteomicsDeep palaeoproteomic profiling of archaeological human brains
Palaeoproteomics leverages the persistence, diversity, and biological import of ancient proteins to explore the past, and answer fundamental questions about phylogeny, environment, diet, and disease. These insights are largely gleaned from hard tissues like bone and teeth, as well-established protoc...
ORGANISM(S): Homo sapiens (Human) 
2025-04-02 | PXD062254 | Pride
Brain  palaeoproteomics  lc-ms/ms  ion mobility  faims 
UnknownMethotrexate-Loaded Liposomal Formulation Enables 6-Week Sustained Intraocular Therapeutic Drug Release in a Porcine Model.
Not available
S-EPMC12790324 | biostudies-literature
UnknownCrystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming.
Not available
S-EPMC3093473 | biostudies-literature
UnknownA variant in the MICA gene is associated with liver fibrosis progression in chronic hepatitis C through TGF-β1 dependent mechanisms.
Not available
S-EPMC6363805 | biostudies-literature
TranscriptomicsWhole blood expression profiling from a general population (KORA F4)
The development of whole genome association studies from the general population has lead to the robust identification of several loci involved in different common human diseases. Interestingly, most of the strongest signals of association observed in these studies arise from non-coding regions, rais...
ORGANISM(S): Homo sapiens 
2013-07-13 | E-MTAB-1708 | biostudies-arrayexpress
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