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ProteomicsParkin-dependent mitophagy occurs via proteasome-dependent stepwise inwardly directed mitochondrial sub-compartment targeting to lysosomes
PINK1/parkin-dependent mitophagy initially involves (phospho) ubiquitin-proteasome-dependent degradation of certain outer mitochondrial membrane (OMM) proteins (e.g. mitofusins) and then the recruitment of autophagy effectors to more stable ubiquitinated OMM proteins. It is widely assumed that such ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD034136 | Pride
Mitochondrial outer membrane  mitophagy  parkin  proteasome  ubiquitin 
ProteomicsInteractome screening of C9orf72 dipeptide repeats reveals sequestration and functional impairment of VCP by polyGA
Repeat expansions in the C9orf72 gene are a common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), two devastating neurodegenerative disorders. One of the proposed mechanisms of GGGGCC repeat expansion is their translation to produce unnatural dipeptide rep...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD024120 | Pride
Proximity labeeling Proteomics Amyotrophic lateral sclerosis Als Valosin-containing protein Vcp Bioid Neurodegeneration Dipeptide repeats 
ProteomicsDeep phosphoproteomics of Klebsiella pneumoniae reveals HipA-mediated tolerance to ciprofloxacin
Klebsiella pneumoniae belongs to the group of bacterial pathogens causing the majority of antibiotic-resistant nosocomial infections worldwide; however, the molecular mechanisms underlying post-translational regulation of its physiology are poorly understood. Here we perform a comprehensive analysis...
ORGANISM(S): Klebsiella pneumoniae subsp. pneumoniae Escherichia coli 
2024-11-21 | PXD051521 | Pride
Phosphoproteome  klebsiella pneumoniae  antibiotic tolerance  persistence  mass spectrometry 
UnknownCannabis Use Disorder Emergency Department Visits and Hospitalizations and 5-Year Mortality.
Not available
S-EPMC11803479 | biostudies-literature
TranscriptomicsExpression profiling of Eµ-Myc-driven lymphomas using a reversible switchable p53 allele modeling early and late stage p53 inactivation.
For the most frequently inactivated tumor suppressor p53, genetic mouse models have demonstrated regression of p53-null tumors upon p53 reactivation. While this was shown in tumor models driven by p53 loss as the initiating lesion, many tumors initially develop in the presence of wild-type p53, acqu...
ORGANISM(S): Mus musculus 
2019-10-18 | E-MTAB-8015 | biostudies-arrayexpress
UnknownShared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies.
Not available
S-EPMC7429266 | biostudies-literature
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