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TranscriptomicsTranscription analysis by RNAseq of adult wheat after inoculation with Puccinia graminis f. sp. tritici
The RNA sequencing analysis was undertaken to investigate the transcriptomic changes in adult wheat inoculated with Puccinia graminis f. sp. tritici the causal agent of stem rust disease. The project firstly aims to compare gene expression in one susceptible wheat line with two wheat lines exhibitin...
ORGANISM(S): Triticum aestivum 
2022-10-30 | E-MTAB-9681 | biostudies-arrayexpress
MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
MetabolomicsRegulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regul...

2023-10-10 | MTBLS8391 | MetaboLights
MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
TranscriptomicsCultured OEC versus cultured SC and versus native OEC
This microarray study aimed at identifying the differences in the global gene expression growth program of adult cultured olfactory ensheathing cells (cOEC) (from the olfactory bulb) versus adult cultured Schwann cells (SC) (from the sciatic nerve) and versus adult OEC directly dissected from the ol...
ORGANISM(S): Rattus norvegicus 
2010-11-02 | E-GEOD-24801 | biostudies-arrayexpress
UnknownTwo Phase 3 Trials of Gantenerumab in Early Alzheimer's Disease.
Not available
S-EPMC10794000 | biostudies-literature
UnknownEffects of airway obstruction and hyperinflation on electrocardiographic axes in COPD.
Not available
S-EPMC6437876 | biostudies-literature
TranscriptomicsTranscription profiling of rat liver to examine aging induced alterations in hepatic gene expression
Toxicokinetic and metabolism studies are considered crucial to dose setting and interpretation of data from rodent carcinogenicity studies. The metabolism and distribution studies are usually conducted in 6 to 8 week old rodents. However cancer studies generally involve exposures from 6 weeks of a...
ORGANISM(S): Rattus norvegicus 
2008-06-18 | E-GEOD-4270 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of autophagy proficient and compromised cell lines, determined by expression levels of Atg5
Autophagy is activated in pancreatic ductal adenocarcinoma (PDAC) and is currently being considered a promising therapeutic target in clinical trials. PDAC is a highly lethal disease with incidence rate equalling mortality rate. Main reasons for PDAC lethality are late-stage diagnosis, high agressiv...
ORGANISM(S): Mus musculus 
2018-10-15 | E-MTAB-6275 | biostudies-arrayexpress
UnknownA small molecule mitigates hearing loss in a mouse model of Usher syndrome III.
Not available
S-EPMC4871731 | biostudies-literature
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