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ProteomicsNeurodegeneration and humoral response proteins in cerebrospinal fluid associate with pediatric-onset multiple sclerosis -- Discovery
The pathogenesis of multiple sclerosis (MS) remains to be elucidated. Pediatric-onset MS (POMS) represents the earliest stage of the disease. CSF proteins in POMS may therefore provide causal information. Therefore, the aim of the current study was to analyze CSF proteins in children with an initial...
ORGANISM(S): Homo sapiens (Human) 
2022-09-30 | PXD031004 | Pride
Proteomics Proteins Mass spectrometry Cerebrospinal fluid Multiple sclerosis Pediatrics 
ProteomicsPhosphoproteomic Analysis of Mec1/ATR Signaling in Response to Different Manners of Kinase Activation
The Mec1/ATR kinase coordinates multiple cellular responses to replication stress. In addition to its canonical role in activating the checkpoint kinase Rad53, Mec1 also plays checkpoint-independent roles in genome maintenance that are not well understood. Here we employed a combined genetic-phospho...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-01-14 | PXD009734 | Pride
Atr Phosphoproteomics Mec1 Dna2 Dpb11 Ddc1 
UnknownA novel mechanism of auxin habituation: upregulation of auxin receptor TRANSPORT INHIBITOR RESPONSE 1 allows cell proliferation independent of external auxin.
Not available
S-EPMC12780323 | biostudies-literature
TranscriptomicsExpression profiling of Eµ-Myc-driven lymphomas using a reversible switchable p53 allele modeling early and late stage p53 inactivation.
For the most frequently inactivated tumor suppressor p53, genetic mouse models have demonstrated regression of p53-null tumors upon p53 reactivation. While this was shown in tumor models driven by p53 loss as the initiating lesion, many tumors initially develop in the presence of wild-type p53, acqu...
ORGANISM(S): Mus musculus 
2019-10-18 | E-MTAB-8015 | biostudies-arrayexpress
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