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TranscriptomicsTuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses
Tuberculosis (TB) remains a major public health problem and we lack a comprehensive understanding of how Mycobacterium tuberculosis (M. tb) infection impacts host immune responses. We compared, at two timepoints, the induced immune response to TB antigen, BCG and IL-1β stimulation between latently M...
ORGANISM(S): Homo sapiens 
2022-11-05 | E-MTAB-12379 | biostudies-arrayexpress
ProteomicsMilking it? Assessing the degradation of ancient milk proteomes
The origins, prevalence and nature of dairying have been long debated by archaeologists. Within the last decade, new advances in high-resolution mass spectrometry have allowed for the direct detection of milk proteins from archaeological remains, including ceramics, dental calculus, and preserved da...
ORGANISM(S): Homo sapiens (Human) 
2021-08-05 | PXD022368 | Pride
Milk Authentication Palaeoproteomics Deamidation 
ProteomicsDeglutarylation of GCDH by SIRT5 controls lysine metabolism in mice
A wide range of protein acyl modifications has been identified on enzymes across various metabolic processes; however, the impact of these modifications remains poorly understood. Protein glutarylation is a recently identified modification that can be non-enzymatically driven by glutaryl-CoA. In mam...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2022-02-21 | PXD018156 | Pride
Gcdh Sirt5 Sirtuins Mitochondria Acylation 
ProteomicsA Mid-Holocene reindeer antler from Regstrup, Sjælland, Denmark
A small, shed antler fragment of a reindeer from Sjælland, Denmark has been dated to the Mid-Holocene, ca., 4700 cal B.C. Reindeer was an important component of the Lateglacial fauna in Denmark, and the species survived for ca. 1400 years into the Holocene. However, we consider it highly unlikely th...
ORGANISM(S): Rangifer tarandus (Reindeer) (Cervus tarandus) 
2021-11-25 | PXD024143 | Pride
Rangifer tarandus Trade Reindeer Stone age Ertebølle culture Denmark Lc-ms/ms 
UnknownDevelopment and Experimental Validation of Regularized Machine Learning Models Detecting New, Structurally Distinct Activators of PXR.
Not available
S-EPMC9029776 | biostudies-literature
ProteomicsPalaeoproteomics of archaeological shell beads
In this project we have applied palaeoproteomics to study archaeological shell beads dating back to the beginning of the 7th mill. cal BCE and recovered from a prehistoric site in Jordan (Ba'ja). These beads were made of mollusc shells and were of unknown origin, but suspected to be made of larger b...
ORGANISM(S): Mollusca 
2024-11-04 | PXD041082 | Pride
Archaeological shells Mollusc shells Ancient proteins Palaeoproteomics Lc-ms/ms 
GenomicsDepletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding (ChIP-seq)
The t(8;21) translocation fuses the DNA binding domain of the hematopoietic master regulator RUNX1 to the ETO protein. The resultant RUNX1/ETO fusion protein is a leukemia-initiating transcription factor that interferes with RUNX1 function. The result of this interference is a block in differentiati...
ORGANISM(S): Homo sapiens 
2012-03-27 | E-GEOD-34540 | biostudies-arrayexpress
TranscriptomicsExtensive imprinted gene expression in Arabidopsis endosperm
Some flowering plant and vertebrate genes are expressed primarily or exclusively from either the maternal or paternal allele, a phenomenon called genomic imprinting. Flowering plant imprinted gene expression has been described primarily in endosperm, a terminal nutritive tissue consumed by the embry...
ORGANISM(S): Arabidopsis thaliana 
2011-03-10 | E-GEOD-24644 | biostudies-arrayexpress
ProteomicsDirect evidence of milk consumption from ancient human dental calculus, northern Europe
This study investigated the consumption of milk products in the archaeological record, utilizing human dental calculus as a reservoir of dietary proteins from archaeological samples from across Eurasia. Protein extraction and generation of tryptic peptides from dental calculus was performed using a ...
ORGANISM(S): Homo sapiens (Human) 
2015-02-25 | PXD001361 | Pride
Human Beta-lactoglobulin Dental calculus Dental plaque Lc-ms/ms 
MetabolomicsAntiviral metabolite 3'-Deoxy-3',4'-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19

BACKGROUND: There is a critical need for rapid viral infection diagnostics to enable prompt case identification in pandemic settings and support targeted antimicrobial prescribing.

METHODS: Using untargeted high-resolution liquid chromatography coupled with...

2022-02-10 | MTBLS718 | MetaboLights
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