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TranscriptomicsGene expression of disseminated neuroblastoma
Comprehensive expression profiling of disseminated neuroblastoma with favorable and unfavorable outcome using SAGE. Results provide insight into the molecular pathogenesis of spontaneous regression and progression of metastatic neuroblastoma and may be used for improving risk estimation of patients ...
ORGANISM(S): Homo sapiens 
2006-09-06 | E-GEOD-4991 | biostudies-arrayexpress
MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
TranscriptomicsGene expression based analysis of CroV infection of Cafeteria roenbergensis
In this study, total RNA was extracted from cultures of Cafeteria infected with the Cafeteria roenbergensis virus BV-PW1 (CroV) and hybridised to a CroV microarray in order to determine the temporal expression profile during infection. A straightforward measure of whether each spot was on or off was...
ORGANISM(S): Cafeteria roenbergensis virus BV-PW1 
2010-07-18 | E-GEOD-19051 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of neuroblastoma tumors with and without MYCN amplification
Purpose: Clinical courses of neuroblastomas (NBs) range from rapid progression with fatal outcome despite intensive multimodality therapies to spontaneous regression. Amplified MYCN oncogene defines a subgroup with poor outcome. However, a substantial number of MYCN single-copy NBs exhibits an aggre...
ORGANISM(S): Homo sapiens 
2007-06-01 | E-CVDE-2 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human neuroblastoma cells with and without MYCN oncogene induction and doxorubicin treatment
Purpose: Clinical courses of neuroblastomas (NBs) range from rapid progression with fatal outcome despite intensive multimodality therapies to spontaneous regression. Amplified MYCN oncogene defines a subgroup with poor outcome. However, a substantial number of MYCN single-copy NBs exhibits an aggre...
ORGANISM(S): Homo sapiens 
2007-06-01 | E-CVDE-3 | biostudies-arrayexpress
TranscriptomicsTranscription profling of human neuroblastoma samples to construct, validate and evalute a gene expression based classification of outcome of treatment
This set of 320 profiles was utilized to construct, validate and evaluate a gene-expression based classifier of outcome of neuroblastoma patients
ORGANISM(S): Homo sapiens 
2009-02-17 | E-TABM-38 | biostudies-arrayexpress
TranscriptomicsMicroarray Quality Control Study 2, Neuroblastoma one-color
This set of profiles was utilized to construct, validate and evaluate a gene-expression based classifier of outcome of neuroblastoma patients
ORGANISM(S): Homo sapiens 
2010-12-31 | E-MTAB-179 | biostudies-arrayexpress
TranscriptomicsComprehensive genomic analysis of relapse neuroblastoma [arrayCGH]
Relapse neuroblastoma were characterized by sequencing, gene expression, arrayCGH and genome-wide methylation. This data set contains the aCGH data. Array from tumours at relapse were compared to pretreatment tumours and corresponding normal samples.
ORGANISM(S): Homo sapiens 
2015-06-19 | E-GEOD-65304 | biostudies-arrayexpress
ProteomicsespL deletion mutant of Mycobacterium tuberculosis
The ESX-1, type VII, secretion system represents the major virulence determinant of Mycobacterium tuberculosis, one of the most successful intracellular pathogens. Here, by combining genetic and high-throughput approaches, we show that EspL, a protein of 115 amino acids, is essential for mediating E...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2018-12-10 | PXD010929 | Pride
Mycobacterium Virulence Tuberculosis Espl 
GenomicsSalt augments macrophage-driven host defense in the skin
Immune cells regulate a hypertonic microenvironment in the skin; however, possible functions of increased skin Na+ concentrations are unknown. We found that Na+ accumulated at the site of bacterial skin infections in humans and in mice. We used the protozoan parasite Leishmania (L.) major as a model...
ORGANISM(S): Mus musculus 
2015-02-26 | E-MTAB-3343 | biostudies-arrayexpress
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